Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | CTSG | P08311 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | CTRC | Q99895 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24701942 | 0.76 | LMNA (0.39) | LMNAPOLBSIGMAR1ELANEF2 | |
| SCHEMBL4084447 | 0.74 | LMNA (0.48) | LMNAPOLBSIGMAR1NPSR1ALDH1A1 | |
| SCHEMBL27586740 | 0.74 | NSD2 (0.40) | LMNASIGMAR1ELANEF2PLG | |
| Hydrochloric Acid SCHEMBL4081730 | 0.73 | LMNA (0.47) | LMNAPOLBSIGMAR1NPSR1KDM4E | |
| SCHEMBL28946773 | 0.71 | POLB (0.50) | LMNAPOLBSIGMAR1ELANEF2 | |
| SCHEMBL1078286 | 0.70 | SIGMAR1 (0.48) | LMNASIGMAR1ELANEF2PLG | |
| SCHEMBL14812572 | 0.70 | ELANE (0.42) | LMNAPOLBSIGMAR1ELANEF2 | |
| SCHEMBL29272014 | 0.70 | MC4R (0.41) | LMNAPOLBSIGMAR1ELANEF2 | |
| SCHEMBL4308587 | 0.69 | LMNA (0.39) | LMNAPOLBSIGMAR1ELANEF2 | |
| SCHEMBL14837485 | 0.69 | CYP19A1 (0.44) | LMNAPOLBKDM4EALDH1A1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1536787-A4 | IMIDAZOLE ALKALOIDS FROM LEPIDIUM MEYENII AND METHODS OF USAGE | PURE WORLD BOTAN INC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1536787-A2 | IMIDAZOLE ALKALOIDS FROM LEPIDIUM MEYENII AND METHODS OF USAGE | Pure World Botanicals, Inc. (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004016216-A3 | IMIDAZOLE ALKALOIDS FROM LEPIDIUM MEYENII AND METHODS OF USAGE | PURE WORLD BOTAN INC (US) | 2004-04-29 | — | — | WO | disclosed |
| WO-2004016216-A2 | IMIDAZOLE ALKALOIDS FROM LEPIDIUM MEYENII AND METHODS OF USAGE | PURE WORLD BOTANICALS, INC. (US) | 2004-02-26 | — | — | WO | disclosed |