Sugi Predict

Sugi Predict / Compounds / SCHEMBL408505

SCHEMBL408505

SCHEMBL408505

CC(C)(C)n1nc(Cc2ccccc2O)c2c(N)ncnc21

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SRC P12931 16/20 0.72
▸ ABL1 P00519 8/20 0.72
▸ PRKD3 O94806 5/20 0.72
▸ PRKD2 Q9BZL6 5/20 0.72
▸ RIPK2 O43353 4/20 0.72
▸ FYN P06241 4/20 0.72
▸ PRKD1 Q15139 4/20 0.72
▸ CSK P41240 3/20 0.72
▸ MAPK8 P45983 3/20 0.72
▸ PRKACA P17612 3/20 0.72
▸ CSNK1A1 P48729 3/20 0.72
▸ MAPK14 Q16539 3/20 0.72
▸ CDK2 P24941 2/20 0.72
▸ CAMK2A Q9UQM7 2/20 0.72
▸ CSNK1E P49674 1/20 0.72
▸ CDK12 Q9NYV4 1/20 0.72
▸ AKT1 P31749 1/20 0.59
▸ HCK P08631 2/20 0.48
▸ CSNK1D P48730 3/20 0.48
▸ PIK3CD O00329 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30250446 1.00 SRC (0.72) SRCABL1PRKD3PRKD2RIPK2
SCHEMBL12551799 0.87 SRC (0.73) SRCABL1PRKD3PRKD2RIPK2
SCHEMBL1961871 0.87 SRC (0.73) SRCABL1PRKD3PRKD2RIPK2
SCHEMBL12551804 0.86 SRC (0.72) SRCABL1PRKD3PRKD2RIPK2
SCHEMBL1962448 0.86 SRC (0.72) SRCABL1PRKD3PRKD2RIPK2
SCHEMBL29387799 0.84 SRC (1.00) SRCABL1PRKD3PRKD2RIPK2
SCHEMBL12551805 0.84 SRC (0.69) SRCABL1PRKD3PRKD2RIPK2
SCHEMBL29390287 0.84 SRC (1.00) SRCABL1PRKD3PRKD2RIPK2
SCHEMBL1960756 0.84 SRC (0.69) SRCABL1PRKD3PRKD2RIPK2
SCHEMBL1964002 0.84 SRC (1.00) SRCABL1PRKD3PRKD2RIPK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9512125-B2 Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-12-06 — — US disclosed
US-9512125-B2 Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-12-06 — — US disclosed
US-20160168151-A1 PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-06-16 — — US disclosed
US-20160168151-A1 PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-06-16 — — US disclosed
US-20150031881-A1 PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-01-29 — — US disclosed
US-20150031881-A1 PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-01-29 — — US disclosed
US-20120065154-A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-03-15 — — US disclosed
US-20120065154-A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-03-15 — — US disclosed
US-20110144134-A1 Anti-Inflammatory Pyrazolopyrimndines THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-06-16 — — US disclosed
US-20090181988-A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-07-16 — — US disclosed
US-20090181988-A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-07-16 — — US disclosed
US-20090124638-A1 ANTI-INFLAMMATORY PYRAZOLOPYRIMIDINES REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-05-14 — — US disclosed
US-20090124638-A1 ANTI-INFLAMMATORY PYRAZOLOPYRIMIDINES REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-05-14 — — US disclosed
US-7429596-B2 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-09-30 — — US disclosed
US-7429596-B2 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-09-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160168151-A1 PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF DPYD, DHODH, DLD SRC 2316/4885ABL1 3212/4885PRKD3 1274/4885
US-20110144134-A1 Anti-Inflammatory Pyrazolopyrimndines TSLP, NLRP3, IL1B SRC 3970/4885ABL1 2987/4885PRKD3 938/4885
US-20150031881-A1 PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF DPYD, DHODH, DLD SRC 2316/4885ABL1 3212/4885PRKD3 1274/4885
US-20090181988-A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof DPYD, DHODH, DLD SRC 2316/4885ABL1 3212/4885PRKD3 1274/4885
US-20090124638-A1 ANTI-INFLAMMATORY PYRAZOLOPYRIMIDINES TNF, TSLP, IL1B SRC 3920/4885ABL1 2533/4885PRKD3 1969/4885
US-20120065154-A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof DPYD, DHODH, DLD SRC 2316/4885ABL1 3212/4885PRKD3 1274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.