Sugi Predict

Sugi Predict / Compounds / SCHEMBL4085704

SCHEMBL4085704

SCHEMBL4085704

Nc1ncnc2c1cnn2C1O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ATG7 O95352 1/20 0.69
▸ ADK P55263 5/20 0.61
▸ DOT1L Q8TEK3 3/20 0.61
▸ DCLK1 O15075 1/20 0.61
▸ DAPK3 O43293 1/20 0.61
▸ DYRK3 O43781 1/20 0.61
▸ CDK1 P06493 1/20 0.61
▸ ROS1 P08922 1/20 0.61
▸ RPS6KB1 P23443 1/20 0.61
▸ CDK2 P24941 1/20 0.61
▸ FLT3 P36888 1/20 0.61
▸ CSNK1A1 P48729 1/20 0.61
▸ CSNK1D P48730 1/20 0.61
▸ CLK2 P49760 1/20 0.61
▸ IRAK1 P51617 1/20 0.61
▸ CDK5 Q00535 1/20 0.61
▸ DYRK1A Q13627 1/20 0.61
▸ MELK Q14680 1/20 0.61
▸ NTRK3 Q16288 1/20 0.61
▸ HIPK4 Q8NE63 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29325546 1.00 ATG7 (0.69) ATG7ADKDOT1LDCLK1DAPK3
SCHEMBL29323418 1.00 ATG7 (0.69) ATG7ADKDOT1LDCLK1DAPK3
SCHEMBL29325550 1.00 ATG7 (0.69) ATG7ADKDOT1LDCLK1DAPK3
SCHEMBL1737936 1.00 ATG7 (0.69) ATG7ADKDOT1LDCLK1DAPK3
SCHEMBL31725281 0.89 ATG7 (0.60) ATG7ADKDOT1LDCLK1DAPK3
SCHEMBL6671707 0.86 ADA (0.54) ATG7ADKDOT1LDCLK1DAPK3
SCHEMBL6672454 0.86 ADA (0.54) ATG7ADKDOT1LDCLK1DAPK3
SCHEMBL11207738 0.86 ADA (0.54) ATG7ADKDOT1LDCLK1DAPK3
SCHEMBL11327761 0.86 ADA (0.54) ATG7ADKDOT1LDCLK1DAPK3
SCHEMBL29325559 0.86 ADA (0.54) ATG7ADKDOT1LDCLK1DAPK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7491818-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2009-02-17 — — US disclosed
US-7291463-B2 Incubating/condensating pseudoisocytidine molecule with (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to provide a pseudouridine molecule; oncology diagnosis AFFYMETRIX, INC. (US) 2007-11-06 — — US disclosed
US-7282327-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2007-10-16 — — US disclosed
US-7179905-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2007-02-20 — — US disclosed
US-20060264390-A1 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase IONIS PHARMACEUTICALS, INC. 2006-11-23 — — US disclosed
US-20060205686-A1 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase BHAT BALKRISHEN 2006-09-14 — — US disclosed
US-6965020-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2005-11-15 — — US disclosed
EP-1589025-A2 Nucleic acid labeling compounds Affymetrix, Inc. (US) 2005-10-26 — — EP disclosed
US-20050164268-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2005-07-28 — — US disclosed
EP-1124838-B1 NUCLEIC ACID LABELING COMPOUNDS AFFYMETRIX INC (US) 2005-06-01 — — EP disclosed
US-20040101892-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2004-05-27 — — US disclosed
US-20040067901-A1 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase MERCK SHARP & DOHME LLC 2004-04-08 — — US disclosed
US-20040002595-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2004-01-01 — — US disclosed
US-20030180757-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2003-09-25 — — US disclosed
US-6596856-B2 For probes, comprising a heterocycle condensed with a cyclic group such as ribofuranose derivative; biotin and 5-carboxyfluorescein derivatives AFFYMETRIX, INC. 2003-07-22 — — US disclosed
US-20020165372-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2002-11-07 — — US disclosed
US-20010044531-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2001-11-22 — — US disclosed
US-20010018514-A1 NUCLEIC ACID LABELING COMPOUNDS AFFYMETRIX, INC. 2001-08-30 — — US disclosed
EP-1124838-A2 NUCLEIC ACID LABELING COMPOUNDS Affymetrix, Inc. (US) 2001-08-22 — — EP disclosed
WO-2000006771-A2 NUCLEIC ACID LABELING COMPOUNDS AFFYMETRIX, INC. (US) 2000-02-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040002595-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL ATG7 3689/4885ADK 454/4885DOT1L 955/4885
US-20040067901-A1 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase NSUN2, NSUN3, POLRMT ATG7 3184/4885ADK 239/4885DOT1L 1622/4885
US-20030180757-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL ATG7 3689/4885ADK 454/4885DOT1L 955/4885
US-20060264390-A1 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase NSUN2, NSUN3, POLRMT ATG7 3184/4885ADK 239/4885DOT1L 1622/4885
US-20050164268-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL ATG7 3689/4885ADK 454/4885DOT1L 955/4885
US-20040101892-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL ATG7 3689/4885ADK 454/4885DOT1L 955/4885
US-20010044531-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL ATG7 3689/4885ADK 454/4885DOT1L 955/4885
US-20010018514-A1 NUCLEIC ACID LABELING COMPOUNDS RNGTT, DUT, FBL ATG7 3689/4885ADK 454/4885DOT1L 955/4885
US-20060205686-A1 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase NSUN2, NSUN3, POLRMT ATG7 3184/4885ADK 239/4885DOT1L 1622/4885
US-20020165372-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL ATG7 3689/4885ADK 454/4885DOT1L 955/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.