SCHEMBL4086143

SCHEMBL4086143

CCOC(=O)c1cc2sc(-c3ccc(OC(C)C)cc3)cc2[nH]1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 9/20 0.49
KDM4E B2RXH2 8/20 0.49
NPC1 O15118 8/20 0.49
MAPT P10636 8/20 0.49
ALDH1A1 P00352 7/20 0.49
SMN1; SMN2 Q16637 7/20 0.49
HPGD P15428 6/20 0.49
MEN1 O00255 5/20 0.49
KMT2A Q03164 5/20 0.49
LMNA P02545 4/20 0.49
GAA P10253 3/20 0.49
GLA P06280 2/20 0.49
ATM Q13315 1/20 0.49
HSD17B10 Q99714 4/20 0.48
TP53 P04637 1/20 0.48
CASP3 P42574 1/20 0.48
SENP8 Q96LD8 1/20 0.48
SENP7 Q9BQF6 1/20 0.48
SENP6 Q9GZR1 1/20 0.48
L3MBTL1 Q9Y468 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31634882 0.88 RAB9A (0.59) RAB9AKDM4ENPC1MAPTALDH1A1
SCHEMBL69116 0.84 HPGD (0.58) RAB9AKDM4ENPC1MAPTALDH1A1
SCHEMBL18034454 0.82 ALDH1A1 (0.54) RAB9AKDM4ENPC1MAPTALDH1A1
SCHEMBL3570965 0.80 MMP13 (0.69) RAB9AKDM4ENPC1MAPTALDH1A1
SCHEMBL4093490 0.77 ALDH1A1 (0.49) RAB9AKDM4ENPC1MAPTALDH1A1
SCHEMBL4086547 0.75 MAPT (0.46) RAB9AKDM4ENPC1MAPTALDH1A1
SCHEMBL1244713 0.74 ALDH1A1 (0.54) RAB9AKDM4ENPC1MAPTALDH1A1
SCHEMBL16763492 0.73 PTPN1 (0.48) RAB9AKDM4ENPC1MAPTALDH1A1
SCHEMBL15850382 0.72 ALDH1A1 (0.51) RAB9AKDM4ENPC1MAPTALDH1A1
SCHEMBL1245047 0.72 ALDH1A1 (0.51) RAB9AKDM4ENPC1MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090069384-A1 THIENOPYRROLES USEFUL IN THE TREATMENT OF INFLAMMATION BIOLIPOX AB (SE) 2009-03-12 US disclosed
EP-1844051-A1 THIENOPYRROLES USEFUL IN THE TREATMENT OF INFLAMMATION Biolipox AB (SE) 2007-10-17 EP disclosed
WO-2006077412-A1 THIENOPYRROLES USEFUL IN THE TREATMENT OF INFLAMMATION BIOLIPOX AB (SE) 2006-07-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090069384-A1 THIENOPYRROLES USEFUL IN THE TREATMENT OF INFLAMMATION NPY5R, TH, PTGES RAB9A 3260/4885KDM4E 583/4885NPC1 4849/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.