Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083540 | 0.84 | FGFR1 (0.50) | MAPK1RAB9ACSNK2A1NPC1KMT2A | |
| SCHEMBL4086452 | 0.82 | MAPK1 (0.46) | MAPK1PKMGAAAPOBEC3GRAB9A | |
| SCHEMBL4083945 | 0.81 | MAPK1 (0.45) | MAPK1PKMGAAAPOBEC3GRAB9A | |
| SCHEMBL4087457 | 0.81 | KLK7 (0.47) | PKMGAARAB9ATDP1TP53 | |
| SCHEMBL4078720 | 0.80 | SMN1; SMN2 (0.46) | MAPK1PKMRAB9ATP53MAPT | |
| SCHEMBL4083484 | 0.80 | SMN1; SMN2 (0.51) | MAPK1PKMRAB9ATDP1TP53 | |
| SCHEMBL4078387 | 0.80 | MAPK1 (0.48) | MAPK1PKMRAB9ATDP1NPC1 | |
| SCHEMBL4078618 | 0.80 | CDK7 (0.35) | MAPK1PKMGAARAB9AMAPT | |
| SCHEMBL4088586 | 0.80 | KCNK3 (0.42) | RAB9AKCNK3KCNK9ADORA3ADORA2A | |
| SCHEMBL4091695 | 0.79 | MAPK1 (0.45) | MAPK1PKMGAAAPOBEC3GRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |