Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (+)-Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 5/20 | 1.00 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 1.00 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (+)-Menthol SCHEMBL10072505 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL15449169 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Isomenthol SCHEMBL677675 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Racementhol SCHEMBL521946 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL9968934 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+) Neomenthol SCHEMBL260049 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL12646785 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL13059620 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Menthol SCHEMBL20771511 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL2454317 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240225915-A1 | COMPOSITIONS FOR FIGHTING MALODORS | SYMRISE AG (DE) | 2024-07-11 | — | — | US | disclosed |
| WO-2023241952-A1 | SHELL-AND-TUBE HEAT EXCHANGE REACTOR FOR CARRYING OUT A CATALYTIC GAS-PHASE PARTIAL OXIDATION REACTION AND PROCESS FOR CARRYING OUT A CATALYTIC GAS-PHASE PARTIAL OXIDATION | BASF SE (DE) | 2023-12-21 | — | — | WO | disclosed |
| US-11738088-B2 | Boryl ethers, carbonates, and cyclic acetals as oxidatively-triggered drug delivery vehicles | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-08-29 | — | — | US | disclosed |
| EP-3470515-B1 | METHOD FOR THE BIOCATALYTIC CYCLISATION OF TERPENES AND CYCLASE MUTANTS WHICH CAN BE USED IN SAME | BASF SE (DE) | 2022-07-13 | — | — | EP | disclosed |
| US-11344488-B2 | Cool-sensation imparter composition containing 2,2,6-trimethylcyclohexanecarboxylic acid derivative | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2022-05-31 | — | — | US | disclosed |
| US-20220120734-A1 | SCREENING METHODS USING CANINE T2R RECEPTORS AND PET FOOD PRODUCTS AND COMPOSITIONS IDENTIFIED USING THE SAME | MARS, INCORPORATED (US) | 2022-04-21 | — | — | US | disclosed |
| US-20210363174-A1 | CATIONIC STEROIDAL ANTIMICROBIAL COMPOUNDS WITH ENDOGENOUS GROUPS | BRIGHAM YOUNG UNIVERSITY (US) | 2021-11-25 | — | — | US | disclosed |
| WO-2021109704-A1 | CHRONIC WOUND HEALING COMPOSITION AND APPLICATION THEREOF | 罗胥恩 | 2021-06-10 | — | — | WO | disclosed |
| EP-3489213-B1 | COMPOSITION FOR USE IN A METHOD FOR THE PREPARATION OF OPTICALLY ACTIVE CARBONYL COMPOUNDS | BASF SE (DE) | 2021-04-28 | — | — | EP | disclosed |
| US-20200407373-A1 | BORONIC ACID DERIVATIVES AND SYNTHESIS THEREOF | QPEX BIOPHARMA, INC. | 2020-12-31 | — | — | US | disclosed |
| US-20080269528-A1 | Method for the Production of Optically Active Carbonyl | BASF AKTIENGESELLSCHAFT (DE) | 2008-10-30 | — | — | US | disclosed |
| US-20080269528-A1 | Method for the Production of Optically Active Carbonyl | BASF AKTIENGESELLSCHAFT (DE) | 2008-10-30 | — | — | US | disclosed |
| US-20080146672-A1 | Topical Eutectic Anesthetic Composition for Oral or Dermal Tissue | DENTON MARCIA MARYE | 2008-06-19 | — | — | US | disclosed |
| US-20080139852-A1 | Method For The Production Of Menthol | BASF AKTIENGESELLSCHAFT (DE) | 2008-06-12 | — | — | US | disclosed |
| US-20080139852-A1 | Method For The Production Of Menthol | BASF AKTIENGESELLSCHAFT (DE) | 2008-06-12 | — | — | US | disclosed |
| US-7247743-B1 | Process for making monomenthyl esters | MILLENNIUM SPECIALTY CHEMICALS, INC. (US) | 2007-07-24 | — | — | US | disclosed |
| US-7189760-B2 | Physiological cooling compositions containing highly purified ethyl ester of N-[[5-methyl-2-(1-methylethyl) cyclohexyl] carbonyl]glycine | MILLENNIUM SPECIALTY CHEMICALS (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189760-B2 | Physiological cooling compositions containing highly purified ethyl ester of N-[[5-methyl-2-(1-methylethyl) cyclohexyl] carbonyl]glycine | MILLENNIUM SPECIALTY CHEMICALS (US) | 2007-03-13 | — | — | US | disclosed |
| US-7169774-B2 | Cephalotaxane derivatives and their processes of preparation and purification | STRAGEN PHARMA S.A. (CH) | 2007-01-30 | — | — | US | disclosed |
| US-7169774-B2 | Cephalotaxane derivatives and their processes of preparation and purification | STRAGEN PHARMA S.A. (CH) | 2007-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210363174-A1 | CATIONIC STEROIDAL ANTIMICROBIAL COMPOUNDS WITH ENDOGENOUS GROUPS | FPR3, NR3C2, HSD17B7 | TRPM8 727/4885TRPA1 1919/4885EPHX1 3827/4885 |
| US-11344488-B2 | Cool-sensation imparter composition containing 2,2,6-trimethylcyclohexanecarboxylic acid derivative | CNR2, ADRB2, TRPA1 | TRPM8 50/4885TRPA1 3/4885EPHX1 2858/4885 |
| US-11738088-B2 | Boryl ethers, carbonates, and cyclic acetals as oxidatively-triggered drug delivery vehicles | BRD8, CA4, LDHA | TRPM8 2725/4885TRPA1 4410/4885EPHX1 1469/4885 |
| US-20200407373-A1 | BORONIC ACID DERIVATIVES AND SYNTHESIS THEREOF | BTD, BLVRB, BLK | TRPM8 4760/4885TRPA1 4704/4885EPHX1 2571/4885 |
| US-20080269528-A1 | Method for the Production of Optically Active Carbonyl | CBR1, CBR3, HMOX1 | TRPM8 2762/4885TRPA1 1175/4885EPHX1 504/4885 |
| US-20220120734-A1 | SCREENING METHODS USING CANINE T2R RECEPTORS AND PET FOOD PRODUCTS AND COMPOSITIONS IDENTIFIED USING THE SAME | TAS2R1, TAS2R50, TAS2R3 | TRPM8 167/4885TRPA1 86/4885EPHX1 3328/4885 |
| US-20080139852-A1 | Method For The Production Of Menthol | NISCH, CYP8B1, MSMO1 | TRPM8 300/4885TRPA1 419/4885EPHX1 601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.