Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 3/20 | 0.84 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.84 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL27906472 | 0.98 | TRPM8 (0.81) | TRPM8TRPA1EPHX1ALDH1A1LMNA | |
| Menthol SCHEMBL20482244 | 0.96 | TRPM8 (0.78) | TRPM8TRPA1EPHX1ALDH1A1LMNA | |
| Menthol SCHEMBL583696 | 0.93 | TRPM8 (0.72) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Levomenthol SCHEMBL2961481 | 0.93 | TRPM8 (0.72) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Menthol SCHEMBL28157641 | 0.92 | TRPM8 (0.84) | TRPM8TRPA1EPHX1ALDH1A1LMNA | |
| Levomenthol SCHEMBL22227514 | 0.92 | TRPM8 (0.84) | TRPM8TRPA1EPHX1ALDH1A1LMNA | |
| Menthol SCHEMBL4086460 | 0.92 | TRPM8 (0.84) | TRPM8TRPA1EPHX1ALDH1A1LMNA | |
| Menthol SCHEMBL20771511 | 0.92 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1LMNA | |
| (+)-Menthol SCHEMBL13059620 | 0.92 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1LMNA | |
| (+)-Menthol SCHEMBL15449169 | 0.92 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118103737-A | Contact lens | 库博光学国际有限公司 | 2024-05-28 | — | — | CN | claimed |
| CN-218280602-U | Menthol rectifying device | 福建卫辰生物技术有限公司（CN） | 2023-01-13 | — | — | CN | claimed |
| EP-1615974-B1 | NON-TOXIC COATING COMPOSITION, METHODS OF USE THEREOF AND ARTICLES PROTECTED FROM ATTACHMENT OF BIOFOULING ORGANISMS | SYMRISE GMBH & CO KG (DE) | 2007-04-04 | — | — | EP | claimed |
| CN-118103737-A | Contact lens | 库博光学国际有限公司 | 2024-05-28 | — | — | CN | disclosed |
| EP-3585185-B1 | METHOD FOR PRODUCING ROTUNDONE-CONTAINING MIXTURES | SYMRISE AG (DE) | 2024-04-10 | — | — | EP | disclosed |
| CN-116829015-A | face mask | 花王株式会社 | 2023-09-29 | — | — | CN | disclosed |
| EP-4247791-A2 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | Symrise AG (DE) | 2023-09-27 | — | — | EP | disclosed |
| WO-2023144326-A1 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | SYMRISE AG (DE) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023143741-A1 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | SYMRISE AG (DE) | 2023-08-03 | — | — | WO | disclosed |
| WO-2022105986-A1 | NOVEL COOLING AGENTS AND PREPARATIONS CONTAINING SAME | SYMRISE AG (DE) | 2022-05-27 | — | — | WO | disclosed |
| WO-2022106452-A2 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | SYMRISE AG (DE) | 2022-05-27 | — | — | WO | disclosed |
| WO-2018153499-A1 | METHOD FOR PRODUCING ROTUNDONE-CONTAINING MIXTURES | SYMRISE AG (DE) | 2018-08-30 | — | — | WO | disclosed |
| US-20180055069-A1 | PREPARATIONS | SYMRISE AG (DE) | 2018-03-01 | — | — | US | disclosed |
| US-20180049449-A1 | PREPARATIONS | SYMRISE AG (DE) | 2018-02-22 | — | — | US | disclosed |
| US-20150313820-A1 | PREPARATIONS | SYMRISE AG (DE) | 2015-11-05 | — | — | US | disclosed |
| US-20150094331-A1 | QUINOLONE INHIBITORS OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2015-04-02 | — | — | US | disclosed |
| EP-2187871-A1 | MIXTURES COMPRISING PELLITORIN AND USES THEREOF | Symrise GmbH & Co. KG (DE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009021558-A1 | MIXTURES COMPRISING PELLITORIN AND USES THEREOF | SYMRISE GMBH & CO. KG (DE) | 2009-02-19 | — | — | WO | disclosed |
| WO-2009021018-A1 | FLAVOR SHEET FOR SMOKING ARTICLE | LORILLARD LICENSING COMPANY, L.L.C. (US) | 2009-02-12 | — | — | WO | disclosed |
| US-7087255-B2 | Chewing gums that provide breath freshening characteristics | WM. WRIGLEY JR. COMPANY (US) | 2006-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150094331-A1 | QUINOLONE INHIBITORS OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 | PLA2G12A, PLA2G4A, PLA2G2A | TRPM8 3134/4885TRPA1 3507/4885EPHX1 213/4885 |
| US-20180049449-A1 | PREPARATIONS | CRAT, ACAT2, TAS2R50 | TRPM8 101/4885TRPA1 188/4885EPHX1 1451/4885 |
| US-20180055069-A1 | PREPARATIONS | CRAT, ACAT2, TAS2R50 | TRPM8 101/4885TRPA1 188/4885EPHX1 1451/4885 |
| US-20150313820-A1 | PREPARATIONS | CRAT, ACAT2, TAS2R50 | TRPM8 101/4885TRPA1 188/4885EPHX1 1451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.