Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CCR1 | P32246 | 2/20 | 0.32 |
| ▸ | CCR5 | P51681 | 2/20 | 0.32 |
| ▸ | CCR8 | P51685 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2721580 | 0.89 | PIK3CD (0.33) | PIK3CDSLC40A1CKS1BSKP2MAPT | |
| SCHEMBL2721578 | 0.77 | PIK3CD (0.45) | PIK3CDSLC40A1CKS1BSKP2MAPT | |
| SCHEMBL2718191 | 0.75 | KDM4E (0.42) | EGLN1MAPTKDM4ECCR1CCR5 | |
| SCHEMBL2011511 | 0.73 | KDM4E (0.40) | EGLN1MAPTKDM4ECCR1CCR5 | |
| SCHEMBL2011836 | 0.73 | LMNA (0.40) | SLC40A1MAPTKDM4ECCR1CCR5 | |
| SCHEMBL2016022 | 0.72 | CCR1 (0.39) | SLC40A1CKS1BSKP2EGLN1MAPT | |
| SCHEMBL2719983 | 0.72 | MET (0.34) | PIK3CDSLC40A1CKS1BSKP2MAPT | |
| SCHEMBL2719987 | 0.72 | MET (0.34) | PIK3CDSLC40A1CKS1BSKP2MAPT | |
| SCHEMBL2718705 | 0.71 | HPGD (0.32) | TDP1 | |
| SCHEMBL4078039 | 0.67 | PTGDR2 (0.37) | MAPTMMP2MMP9MMP13MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |