Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.39 |
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | CCR8 | P51685 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718191 | 0.82 | KDM4E (0.42) | CCR1CCR5CCR8TDP1KDM4E | |
| SCHEMBL2011836 | 0.80 | LMNA (0.40) | CCR1CCR5CCR8TDP1KDM4E | |
| SCHEMBL2011511 | 0.80 | KDM4E (0.40) | CCR1CCR5CCR8TDP1KDM4E | |
| SCHEMBL2721112 | 0.80 | ERN1 (0.43) | CCR1CCR5CCR8TDP1KDM4E | |
| SCHEMBL2014257 | 0.79 | KDM4E (0.42) | CCR1CCR5CCR8TDP1KDM4E | |
| SCHEMBL15445451 | 0.73 | ALDH1A1 (0.43) | CCR1CCR5CCR8TDP1KDM4E | |
| SCHEMBL2016020 | 0.72 | ALDH1A1 (0.44) | CCR1CCR5CCR8TDP1KDM4E | |
| SCHEMBL6225626 | 0.72 | KDM4E (0.48) | CCR1CCR5CCR8TDP1KDM4E | |
| SCHEMBL4086659 | 0.72 | PIK3CD (0.34) | CCR1CCR5CCR8TDP1KDM4E | |
| SCHEMBL2015218 | 0.71 | CDC7 (0.40) | TDP1KDM4ELMNAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |