Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2721580 | 0.83 | PIK3CD (0.33) | TDP1 | |
| SCHEMBL2718141 | 0.78 | LMNA (0.36) | HPGDSLC2A1MTNR1A | |
| SCHEMBL2546674 | 0.76 | PTPN1 (0.37) | — | |
| SCHEMBL2717827 | 0.73 | TAAR1 (0.41) | CTDSP1TDP1 | |
| SCHEMBL21063772 | 0.68 | RIPK1 (0.37) | — | |
| SCHEMBL21815093 | 0.66 | ANO1 (0.36) | MTNR1AMTNR1B | |
| SCHEMBL2721106 | 0.66 | RPS27 (0.32) | — | |
| SCHEMBL28161575 | 0.66 | ALOX5 (0.50) | HPGDCTDSP1TDP1 | |
| SCHEMBL14134412 | 0.66 | CYP2A6 (0.47) | HPGDCTDSP1TDP1 | |
| SCHEMBL17981892 | 0.65 | LOXL2 (0.44) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635565-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | Amgen Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |