Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.59 |
| ▸ | DPP4 | P27487 | 5/20 | 0.55 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.53 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.53 |
| ▸ | FAP | Q12884 | 1/20 | 0.53 |
| ▸ | TACR1 | P25103 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4095232 | 1.00 | HDAC8 (0.59) | HDAC8OPRD1DPP4DPP7POLB | |
| SCHEMBL6052747 | 1.00 | HDAC8 (0.59) | HDAC8OPRD1DPP4DPP7POLB | |
| SCHEMBL6161830 | 0.92 | OPRD1 (0.65) | HDAC8OPRD1DPP4DPP7POLB | |
| SCHEMBL3133533 | 0.92 | OPRD1 (0.65) | HDAC8OPRD1DPP4DPP7POLB | |
| Hydrochloric Acid SCHEMBL6162439 | 0.91 | HDAC8 (0.58) | HDAC8OPRD1DPP4DPP7POLB | |
| Hydrochloric Acid SCHEMBL6163301 | 0.90 | HDAC8 (0.63) | HDAC8OPRD1DPP4DPP7POLB | |
| Hydrochloric Acid SCHEMBL6165745 | 0.90 | HDAC8 (0.63) | HDAC8OPRD1DPP4DPP7POLB | |
| Hydrochloric Acid SCHEMBL6163295 | 0.90 | HDAC8 (0.63) | HDAC8OPRD1DPP4DPP7POLB | |
| SCHEMBL27545467 | 0.88 | HDAC8 (0.66) | HDAC8OPRD1DPP4DPP7POLB | |
| SCHEMBL6052908 | 0.88 | HDAC8 (0.66) | HDAC8OPRD1DPP4DPP7POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023703-A1 | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase | PROSIDION LIMITED (GB) | 2009-01-22 | — | — | US | disclosed |
| US-7405210-B2 | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase | OSI PHARMACEUTICALS, INC. (US) | 2008-07-29 | — | — | US | disclosed |
| US-20070244090-A9 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSPHORYLASE | BRADLEY STUART E | 2007-10-18 | — | — | US | disclosed |
| US-20050261272-A1 | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase | PROSIDION LIMITED (GB) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244090-A9 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSPHORYLASE | PYGL, PYGM, PYGB | HDAC8 1898/4885OPRD1 3457/4885DPP4 226/4885 |
| US-20090023703-A1 | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase | PYGL, PYGM, PYGB | HDAC8 1898/4885OPRD1 3457/4885DPP4 226/4885 |
| US-20050261272-A1 | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase | PYGL, PYGM, PYGB | HDAC8 1898/4885OPRD1 3457/4885DPP4 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.