Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | PRKX | P51817 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | STK3 | Q13188 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088609 | 0.88 | AURKA (0.49) | FLT3CDK2CDC7DAPK3ROCK2 | |
| SCHEMBL4086831 | 0.86 | AURKA (0.54) | FLT3CDC7PAK4PRKACAJAK3 | |
| SCHEMBL4088635 | 0.85 | AURKA (0.58) | FLT3AURKA | |
| SCHEMBL4086290 | 0.84 | MAPT (0.40) | KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4088217 | 0.81 | AURKA (0.51) | CDK2ROCK2CDK7AURKAHDAC6 | |
| SCHEMBL3879252 | 0.80 | GPR35 (0.45) | FLT3CDK2CDC7DAPK3ROCK2 | |
| SCHEMBL4083527 | 0.80 | HDAC6 (0.42) | FLT3CDK2CDC7DAPK3ROCK2 | |
| SCHEMBL4082950 | 0.79 | AURKA (0.44) | FLT3CDK2CDC7DAPK3ROCK2 | |
| SCHEMBL4092679 | 0.79 | AURKA (0.49) | FLT3CDK2CDC7DAPK3ROCK2 | |
| SCHEMBL739913 | 0.78 | AURKA (0.42) | FLT3CDK2CDC7DAPK3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |