Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973752 | 0.81 | ALDH1A1 (0.46) | RAB9AALDH1A1TP53TSHRMAPK1 | |
| SCHEMBL11816669 | 0.81 | ALDH1A1 (0.52) | CYP2C19ALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL3971781 | 0.79 | ALDH1A1 (0.46) | POLBCYP2C19ALDH1A1HDAC3HDAC4 | |
| SCHEMBL3972855 | 0.79 | SMN1; SMN2 (0.47) | PLAUIDO1ALDH1A1HDAC3HDAC4 | |
| SCHEMBL4086338 | 0.78 | — | — | |
| SCHEMBL3969996 | 0.77 | MLYCD (0.43) | PLAUCYP2C19IDO1ALDH1A1MLYCD | |
| SCHEMBL4087920 | 0.77 | MEN1 (0.39) | NPC1IDO1MLYCDNOS1 | |
| SCHEMBL3973730 | 0.75 | ADRA2A (0.46) | POLBALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL4086856 | 0.75 | GBA1 (0.44) | PLAUNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL3968468 | 0.74 | MAPK1 (0.40) | NPC1RAB9AALDH1A1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053448-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2009-04-30 | — | — | WO | disclosed |