Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | TSHR | P16473 | 5/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | PLG | P00747 | 1/20 | 0.53 |
| ▸ | PLAU | P00749 | 1/20 | 0.53 |
| ▸ | PLAT | P00750 | 1/20 | 0.53 |
| ▸ | KLK1 | P06870 | 1/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TDP2 | O95551 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31178856 | 0.98 | ALDH1A1 (0.52) | ALDH1A1TSHRCYP3A4HPGDHSD17B10 | |
| SCHEMBL4083992 | 0.83 | CYP3A4 (0.54) | ALDH1A1TSHRCYP3A4HPGDHSD17B10 | |
| SCHEMBL31179229 | 0.83 | CYP3A4 (0.54) | ALDH1A1TSHRCYP3A4HPGDHSD17B10 | |
| SCHEMBL29498396 | 0.77 | CTDSP1 (0.63) | ALDH1A1TSHRCYP3A4HPGDHSD17B10 | |
| SCHEMBL29405526 | 0.77 | CTDSP1 (0.63) | ALDH1A1TSHRCYP3A4HPGDHSD17B10 | |
| SCHEMBL729842 | 0.77 | CTDSP1 (0.63) | ALDH1A1TSHRCYP3A4HPGDHSD17B10 | |
| SCHEMBL30366567 | 0.77 | CYP2A6 (0.58) | ALDH1A1TSHRCYP3A4HSD17B10TDP1 | |
| SCHEMBL6561452 | 0.77 | CYP2A6 (0.58) | ALDH1A1TSHRCYP3A4HSD17B10TDP1 | |
| SCHEMBL29351158 | 0.76 | ALDH1A1 (0.62) | ALDH1A1TSHRCYP3A4HPGDHSD17B10 | |
| SCHEMBL5545202 | 0.76 | ALDH1A1 (0.62) | ALDH1A1TSHRCYP3A4HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106467476-A | A kind of synthetic method of left-handed amine compound | 王际菊 | 2017-03-01 | — | — | CN | claimed |
| EP-4209492-A1 | COMPOUND FOR TREATING THROMBOTIC DISEASES | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2023-07-12 | — | — | EP | disclosed |
| WO-2022258057-A1 | COMPOUNDS AS ANTICANCER AGENTS | JINGRUI BIOPHARMA CO., LTD. (CN) | 2022-12-15 | — | — | WO | disclosed |
| US-10793584-B2 | Naphthobischalcogenadiazole derivative and production method therefor | OSAKA UNIVERSITY (JP) | 2020-10-06 | — | — | US | disclosed |
| US-20190337966-A1 | NAPHTHOBISCHALCOGENADIAZOLE DERIVATIVE AND PRODUCTION METHOD THEREFOR | OSAKA UNIVERSITY (JP) | 2019-11-07 | — | — | US | disclosed |
| US-10398679-B2 | Treatment method utilizing pyrrolidine-2, 5-dione derivatives as IDO1 inhibitors | ITEOS THERAPEUTICS (BE) | 2019-09-03 | — | — | US | disclosed |
| US-10398679-B2 | Treatment method utilizing pyrrolidine-2, 5-dione derivatives as IDO1 inhibitors | ITEOS THERAPEUTICS (BE) | 2019-09-03 | — | — | US | disclosed |
| CN-106536480-B | Pyrrolidine-2, 5-dione derivatives, pharmaceutical compositions and methods for use as IDO1 inhibitors | 艾特奥斯治疗公司 | 2019-09-03 | — | — | CN | disclosed |
| US-20180214415-A1 | TREATMENT METHOD UTILIZING PYRROLIDINE-2, 5-DIONE DERIVATIVES AS IDO1 INHIBITORS | ITEOS THERAPEUTICS (BE) | 2018-08-02 | — | — | US | disclosed |
| US-20180214415-A1 | TREATMENT METHOD UTILIZING PYRROLIDINE-2, 5-DIONE DERIVATIVES AS IDO1 INHIBITORS | ITEOS THERAPEUTICS (BE) | 2018-08-02 | — | — | US | disclosed |
| CN-106467476-A | A kind of synthetic method of left-handed amine compound | 王际菊 | 2017-03-01 | — | — | CN | disclosed |
| US-20170035731-A1 | PYRROLIDINE-2, 5-DIONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE AS IDO1 INHIBITORS | ITEOS THERAPEUTICS (BE) | 2017-02-09 | — | — | US | disclosed |
| US-20170035731-A1 | PYRROLIDINE-2, 5-DIONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE AS IDO1 INHIBITORS | ITEOS THERAPEUTICS (BE) | 2017-02-09 | — | — | US | disclosed |
| US-20150329525-A1 | PYRROLIDINE-2, 5-DIONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE AS IDO1 INHIBITORS | ITEOS THERAPEUTICS (BE) | 2015-11-19 | — | — | US | disclosed |
| WO-2015173764-A1 | PYRROLIDINE-2,5-DIONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE AS IDO1 INHIBITORS | ITEOS THERAPEUTICS (BE) | 2015-11-19 | — | — | WO | disclosed |
| CN-1863784-B | 2-naphthylimino-1,3-thiazine derivative | SHIONOGI & CO | 2010-11-17 | — | — | CN | disclosed |
| US-7482339-B2 | 2-Naphthylimino-1,3-thiazine derivative | SHIONOGI AND CO., LTD. (JP) | 2009-01-27 | — | — | US | disclosed |
| US-20060281738-A1 | 2-Naphthylimino-1,3-thiazine derivative | SHIONOGI AND CO., LTD. (JP) | 2006-12-14 | — | — | US | disclosed |
| CN-1863784-A | 2-naphthylimino-1,3-thiazine derivative | SHIONOGI & CO (JP) | 2006-11-15 | — | — | CN | disclosed |
| EP-1659117-A1 | 2-NAPHTHYLIMINO-1,3-THIAZINE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2006-05-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10793584-B2 | Naphthobischalcogenadiazole derivative and production method therefor | CYP24A1, CYP26B1, CYP21A2 | ALDH1A1 600/4885TSHR 1397/4885CYP3A4 389/4885 |
| US-20190337966-A1 | NAPHTHOBISCHALCOGENADIAZOLE DERIVATIVE AND PRODUCTION METHOD THEREFOR | CYP24A1, CYP26B1, CYP21A2 | ALDH1A1 600/4885TSHR 1397/4885CYP3A4 389/4885 |
| US-20060281738-A1 | 2-Naphthylimino-1,3-thiazine derivative | NPM1, OXTR, CYP2S1 | ALDH1A1 1571/4885TSHR 440/4885CYP3A4 95/4885 |
| US-20170035731-A1 | PYRROLIDINE-2, 5-DIONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE AS IDO1 INHIBITORS | IDO1, IDO2, ARG1 | ALDH1A1 357/4885TSHR 4401/4885CYP3A4 905/4885 |
| US-20150329525-A1 | PYRROLIDINE-2, 5-DIONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE AS IDO1 INHIBITORS | IDO1, IDO2, ARG1 | ALDH1A1 212/4885TSHR 4368/4885CYP3A4 437/4885 |
| US-20180214415-A1 | TREATMENT METHOD UTILIZING PYRROLIDINE-2, 5-DIONE DERIVATIVES AS IDO1 INHIBITORS | IDO1, IDO2, NAT1 | ALDH1A1 241/4885TSHR 4356/4885CYP3A4 910/4885 |
| US-10398679-B2 | Treatment method utilizing pyrrolidine-2, 5-dione derivatives as IDO1 inhibitors | IDO1, IDO2, NAT1 | ALDH1A1 241/4885TSHR 4356/4885CYP3A4 910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.