Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | BCR | P11274 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.37 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081465 | 0.90 | ABL1 (0.54) | AURKAABL1BCRHTTMAPK1 | |
| SCHEMBL4088215 | 0.86 | HTT (0.57) | AURKAHTTMAPK1SMN1; SMN2NPC1 | |
| SCHEMBL4092903 | 0.83 | ABL1 (0.61) | AURKAABL1BCRRAB9AALDH1A1 | |
| SCHEMBL4083868 | 0.83 | ABL1 (0.59) | AURKAABL1BCRRAB9AALDH1A1 | |
| SCHEMBL4081436 | 0.82 | AURKA (0.57) | AURKAABL1BCRHIF1AEPAS1 | |
| SCHEMBL4093502 | 0.82 | ABL1 (0.63) | AURKAABL1BCRRAB9AALDH1A1 | |
| SCHEMBL4081182 | 0.82 | AURKA (0.61) | AURKAABL1BCR | |
| SCHEMBL4078785 | 0.81 | AURKA (0.42) | AURKAABL1BCRHTTMAPK1 | |
| SCHEMBL4088344 | 0.80 | RAB9A (0.46) | AURKAABL1BCRMAPK1SMN1; SMN2 | |
| SCHEMBL4088217 | 0.79 | AURKA (0.51) | AURKAABL1BCRHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |