Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088428 | 0.90 | HSD11B1 (0.39) | HSD11B1HSD11B2SCN9A | |
| SCHEMBL75654 | 0.89 | HSD11B1 (0.42) | HSD11B1HSD11B2ALDH1A1 | |
| SCHEMBL75774 | 0.83 | HSD11B1 (0.48) | HSD11B1 | |
| SCHEMBL75923 | 0.72 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL77369 | 0.72 | HSD11B1 (0.44) | HSD11B1 | |
| SCHEMBL4081955 | 0.72 | DGAT1 (0.37) | HSD11B1HSD11B2KMT2ASCN9A | |
| SCHEMBL75902 | 0.72 | HSD11B1 (0.39) | HSD11B1HSD11B2SCN9A | |
| SCHEMBL1116549 | 0.72 | HSD11B1 (0.41) | HSD11B1ALDH1A1 | |
| SCHEMBL4083612 | 0.71 | SCN9A (0.39) | HSD11B1HSD11B2SCN9AALDH1A1 | |
| SCHEMBL4083851 | 0.71 | SCN9A (0.39) | HSD11B1HSD11B2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |