Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.35 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL75617 | 0.89 | HSD11B1 (0.46) | DGAT1KMT2AHSD11B1HSD11B2PRMT5 | |
| SCHEMBL4084557 | 0.86 | SCN9A (0.39) | HSD11B1HSD11B2SCN9A | |
| SCHEMBL4079305 | 0.86 | TOP2A (0.39) | KMT2AHSD11B1HSD11B2SCN9A | |
| SCHEMBL75902 | 0.85 | HSD11B1 (0.39) | HSD11B1HSD11B2SCN9A | |
| SCHEMBL75977 | 0.84 | HSD11B1 (0.42) | KMT2AHSD11B1PRMT5WDR77 | |
| SCHEMBL4079039 | 0.84 | SCN9A (0.43) | HSD11B1HSD11B2SCN9A | |
| SCHEMBL4083851 | 0.81 | SCN9A (0.39) | HSD11B1HSD11B2SCN9A | |
| SCHEMBL4083612 | 0.81 | SCN9A (0.39) | DGAT1HSD11B1HSD11B2SCN9A | |
| SCHEMBL4089235 | 0.78 | SCN9A (0.39) | KMT2AHSD11B1SCN9A | |
| SCHEMBL4258533 | 0.75 | ALDH1A1 (0.36) | HSD11B1HSD11B2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |