Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 13/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089235 | 0.89 | SCN9A (0.39) | SCN9AHSD11B1CNR2 | |
| SCHEMBL4083851 | 0.89 | SCN9A (0.39) | SCN9AHSD11B1CNR2P2RX7HSD11B2 | |
| SCHEMBL75857 | 0.88 | HSD11B1 (0.48) | HSD11B1HSD11B2 | |
| SCHEMBL75638 | 0.84 | HSD11B1 (0.43) | HSD11B1HSD11B2 | |
| SCHEMBL4084557 | 0.84 | SCN9A (0.39) | SCN9AHSD11B1ALDH1A1HSD11B2 | |
| SCHEMBL4079039 | 0.81 | SCN9A (0.43) | SCN9AHSD11B1ALDH1A1NPSR1HSD11B2 | |
| SCHEMBL74426 | 0.81 | HSD11B1 (0.41) | HSD11B1ALDH1A1CNR2SMN1; SMN2NPSR1 | |
| SCHEMBL4081955 | 0.81 | DGAT1 (0.37) | SCN9AHSD11B1HSD11B2DGAT1 | |
| SCHEMBL75902 | 0.79 | HSD11B1 (0.39) | SCN9AHSD11B1NPSR1P2RX7HSD11B2 | |
| SCHEMBL4079305 | 0.78 | TOP2A (0.39) | SCN9AHSD11B1ALDH1A1CNR2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |