SCHEMBL4089334

SCHEMBL4089334

CCC(C)NC(=O)N1CC(OC(c2ccc(OC(F)F)cc2)c2ccccc2C(F)(F)F)C1

nearest known ligand 0.40

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 3/20 0.40
RBP4 P02753 5/20 0.39
FAAH O00519 7/20 0.38
GPR139 Q6DWJ6 1/20 0.36
MAPK1 P28482 1/20 0.36
CNR2 P34972 2/20 0.36
ACACB O00763 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29574824 0.91 CNR1 (0.48) CNR1RBP4FAAHACACB
SCHEMBL4075637 0.91 CNR1 (0.48) CNR1RBP4FAAHACACB
SCHEMBL4085186 0.90 CNR1 (0.40) CNR1RBP4FAAHGPR139CNR2
SCHEMBL4079269 0.90 RBP4 (0.43) CNR1RBP4FAAHCNR2
SCHEMBL4079274 0.89 FAAH (0.42) CNR1RBP4FAAHCNR2
SCHEMBL4089341 0.89 CNR1 (0.52) CNR1FAAHCNR2
SCHEMBL29574730 0.89 CNR1 (0.52) CNR1FAAHCNR2
SCHEMBL5801936 0.87 RBP4 (0.38) CNR1RBP4FAAHCNR2
SCHEMBL4075844 0.87 CNR1 (0.40) CNR1RBP4FAAHCNR2
SCHEMBL4079397 0.87 RBP4 (0.40) CNR1RBP4FAAHCNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1620395-B1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RES LTD (GB) 2009-12-30 EP claimed
US-7504522-B2 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders VERNALIS RESEARCH LIMITED (GB) 2009-03-17 US claimed
US-20070054891-A1 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders VERNALIS RESEARCH LIMAITED (GB) 2007-03-08 US claimed
US-20240000748-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE ANEBULO PHARMACEUTICALS, INC. 2024-01-04 US disclosed
US-20220151990-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE ANEBULO PHARMACEUTICALS, INC. 2022-05-19 US disclosed
US-11141404-B1 Formulations and methods for treating acute cannabinoid overdose ANEBULO PHARMACEUTICALS, INC. (US) 2021-10-12 US disclosed
EP-1620395-B1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RES LTD (GB) 2009-12-30 EP disclosed
US-7504522-B2 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders VERNALIS RESEARCH LIMITED (GB) 2009-03-17 US disclosed
US-20070054891-A1 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders VERNALIS RESEARCH LIMAITED (GB) 2007-03-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070054891-A1 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders CNR1, CNR2, GPR119 CNR1 1/4885RBP4 2267/4885FAAH 8/4885
US-20240000748-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE CNR1, CNR2, FAAH CNR1 1/4885RBP4 3417/4885FAAH 3/4885
US-20220151990-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE CNR1, CNR2, FAAH CNR1 1/4885RBP4 3417/4885FAAH 3/4885
US-11141404-B1 Formulations and methods for treating acute cannabinoid overdose CNR1, CNR2, FAAH CNR1 1/4885RBP4 3417/4885FAAH 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.