Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 5/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 5/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 7/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.43 |
| ▸ | CDK2 | P24941 | 7/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 7/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | SIK1 | P57059 | 1/20 | 0.41 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.41 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3766648 | 0.86 | FGFR1 (0.51) | RIPK2NOD2ACVR1MAPK14CCND1 | |
| SCHEMBL29785435 | 0.83 | PIK3CA (0.51) | RIPK2NOD2ACVR1ABL1 | |
| SCHEMBL20674135 | 0.83 | PIK3CA (0.51) | RIPK2NOD2ACVR1ABL1 | |
| SCHEMBL4083936 | 0.83 | RIPK2 (0.65) | RIPK2NOD2ACVR1LCKMAPK14 | |
| SCHEMBL4147310 | 0.83 | MAPK14 (0.44) | LCKMAPK14CCND1CCNE1CDK2 | |
| SCHEMBL25123123 | 0.81 | CCNE1 (0.62) | CCND1CCNE1CDK2CDK6CCNT1 | |
| SCHEMBL30836981 | 0.81 | CCNE1 (0.62) | CCND1CCNE1CDK2CDK6CCNT1 | |
| SCHEMBL4157046 | 0.80 | DRD2 (0.42) | CCND1CCNE1CDK2CDK6CCNT1 | |
| SCHEMBL4084205 | 0.79 | CCND1 (0.54) | LCKMAPK14CCND1CCNE1CDK2 | |
| SCHEMBL28382929 | 0.79 | RIPK2 (0.39) | RIPK2NOD2ACVR1LCKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131430-A1 | PYRIDO'2,3-DIPYRIMIDINES AS ANTI-INFLAMMATORY AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2009-05-21 | — | — | US | disclosed |
| WO-2008078249-A1 | ANTI-INFLAMMATORY AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2008-07-03 | — | — | WO | disclosed |
| EP-1831215-A1 | PYRIDO[2,3-D]PYRIMIDINES AS ANTI-INFLAMATORY AGENTS | Ranbaxy Laboratories Limited (IN) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006056863-A1 | PYRIDO’2, 3-D!PYRIMIDINES AS ANTI-INFLAMMATORY AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2006-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131430-A1 | PYRIDO'2,3-DIPYRIMIDINES AS ANTI-INFLAMMATORY AGENTS | TLR1, TPMT, NOD1 | RIPK2 955/4885NOD2 48/4885ACVR1 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.