SCHEMBL4091568

SCHEMBL4091568

COC(=O)c1cc(Nc2ccc(C)cc2)c(C(=O)OC)cc1Nc1ccc(C)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 5/20 0.59
AKR1C2 P52895 5/20 0.59
MAPT P10636 4/20 0.53
ALOX15 P16050 1/20 0.53
KDM4E B2RXH2 6/20 0.51
ALDH1A1 P00352 4/20 0.51
LMNA P02545 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
HPGD P15428 3/20 0.50
TDP1 Q9NUW8 2/20 0.50
KMT2A Q03164 2/20 0.47
MITF O75030 1/20 0.47
POLB P06746 1/20 0.47
NPC1 O15118 1/20 0.46
GAA P10253 1/20 0.46
GFER P55789 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
SIRT2 Q8IXJ6 1/20 0.45
EGFR P00533 1/20 0.45
NR4A2 P43354 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4254887 0.94 AKR1C3 (0.65) AKR1C3AKR1C2MAPTALOX15KDM4E
SCHEMBL8834176 0.93 AKR1C3 (0.55) AKR1C3AKR1C2MAPTALOX15KDM4E
SCHEMBL29115118 0.90 MAPT (0.54) AKR1C3AKR1C2MAPTALOX15KDM4E
SCHEMBL9409087 0.87 AKR1C3 (0.61) AKR1C3AKR1C2MAPTALOX15KDM4E
SCHEMBL9409094 0.85 SIRT2 (0.54) AKR1C3AKR1C2MAPTALOX15KDM4E
SCHEMBL31606264 0.84 ALDH1A1 (0.56) AKR1C3AKR1C2MAPTALOX15KDM4E
SCHEMBL9513240 0.84 AKR1C3 (0.67) AKR1C3AKR1C2MAPTALOX15KDM4E
SCHEMBL28258480 0.84 AKR1C3 (0.60) AKR1C3AKR1C2MAPTALOX15LMNA
SCHEMBL8529851 0.84 MAPT (0.74) AKR1C3AKR1C2MAPTALOX15KDM4E
SCHEMBL28658698 0.83 MAPT (0.78) AKR1C3AKR1C2MAPTALOX15KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020149439-A1 CONDUCTIVE ADHESIVE COMPOSITION AND CONDUCTIVE ADHESIVE FILM USING SAME 주식회사 제이에이치씨 2020-07-23 WO disclosed
US-8263771-B2 Method for manufacturing dispersion of quinoline derivative CANON KABUSHIKI KAISHA (JP) 2012-09-11 US disclosed
US-8263771-B2 Method for manufacturing dispersion of quinoline derivative CANON KABUSHIKI KAISHA (JP) 2012-09-11 US disclosed
US-20090020043-A1 METHOD FOR MANUFACTURING DISPERSION OF QUINOLINE DERIVATIVE CANON KABUSHIKI KAISHA (JP) 2009-01-22 US disclosed
US-20090020043-A1 METHOD FOR MANUFACTURING DISPERSION OF QUINOLINE DERIVATIVE CANON KABUSHIKI KAISHA (JP) 2009-01-22 US disclosed
US-20090017307-A1 Process for the Preparation of Organic Materials MCA TECHNOLOGIES, GMBH (CH) 2009-01-15 US disclosed
US-20090017307-A1 Process for the Preparation of Organic Materials MCA TECHNOLOGIES, GMBH (CH) 2009-01-15 US disclosed
US-20080060554-A1 Process for the Preparation of Organic Materials MCA TECHNOLOGIES, GMBH (CH) 2008-03-13 US disclosed
US-20080060554-A1 Process for the Preparation of Organic Materials MCA TECHNOLOGIES, GMBH (CH) 2008-03-13 US disclosed
US-20070119345-A1 Process for the preparation of organic materials MCA TECHNOLOGIES, GMBH (CH) 2007-05-31 US disclosed
US-20070119345-A1 Process for the preparation of organic materials MCA TECHNOLOGIES, GMBH (CH) 2007-05-31 US disclosed
EP-1725619-A1 PROCESS FOR THE PREPARATION OF ORGANIC PIGMENTS MCA Technologies GMBH (CH) 2006-11-29 EP disclosed
WO-2005085364-A1 PROCESS FOR THE PREPARATION OF ORGANIC PIGMENTS MCA TECHNOLOGIES GMBH (CH) 2005-09-15 WO disclosed
EP-0558511-B1 METHOD OF PREPARING 2,5-DI(PHENYLAMINO)TEREPHTHALIC ACID AND ITS DIALKYL ESTERS AS HIGH-PURITY PRODUCTS HOECHST AG (DE) 1996-04-17 EP disclosed
EP-0518351-B1 Process for the preparation of 2,5-di(phenylamino)terephthalic acids and their dialkylesters in high purity HOECHST AG (DE) 1995-05-10 EP disclosed
US-5347038-A Starting material for quinacridone pigments, pollution control, from succinic acid diester and aniline HOECHST AKTIENGESELLSCHAFT (DE) 1994-09-13 US disclosed
EP-0558511-A1 METHOD OF PREPARING 2,5-DI(PHENYLAMINO)TEREPHTHALIC ACID AND ITS DIALKYL ESTERS AS HIGH-PURITY PRODUCTS. HOECHST AG (DE) 1993-09-08 EP disclosed
US-5208365-A PROCESS FOR THE PREPARATION OF 2,5-DI(PHENYLAMINO)-TEREPHTHALIC ACID AND ITS DIALKYL ESTERS IN HIGH PURITY HOECHST AKTIENGESELLSCHAFT (DE) 1993-05-04 US disclosed
EP-0518351-A2 Process for the preparation of 2,5-di(phenylamino)terephthalic acids and their dialkylesters in high purity HOECHST AKTIENGESELLSCHAFT (DE) 1992-12-16 EP disclosed
WO-1992009558-A1 METHOD OF PREPARING 2,5-DI(PHENYLAMINO)TEREPHTHALIC ACID AND ITS DIALKYL ESTERS AS HIGH-PURITY PRODUCTS HOECHST AKTIENGESELLSCHAFT (DE) 1992-06-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090017307-A1 Process for the Preparation of Organic Materials KLK4, PDK4, GRK1 AKR1C3 196/4885AKR1C2 321/4885MAPT 687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.