Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8834176 | 0.92 | AKR1C3 (0.55) | SIRT2AKR1C3AKR1C2MAPTNPC1 | |
| SCHEMBL9409101 | 0.91 | MAPT (0.54) | SIRT2AKR1C3AKR1C2MAPTNPC1 | |
| SCHEMBL9409104 | 0.87 | SIRT2 (0.52) | SIRT2MAPTNPC1SMN1; SMN2RAB9A | |
| SCHEMBL9409132 | 0.87 | AKR1C3 (0.55) | SIRT2AKR1C3AKR1C2MAPTNPC1 | |
| SCHEMBL9409202 | 0.86 | MAPT (0.64) | SIRT2AKR1C3AKR1C2MAPTALOX15 | |
| SCHEMBL9409087 | 0.86 | AKR1C3 (0.61) | AKR1C3AKR1C2MAPTNPC1SMN1; SMN2 | |
| SCHEMBL4091568 | 0.85 | AKR1C3 (0.59) | SIRT2AKR1C3AKR1C2MAPTNPC1 | |
| SCHEMBL9409210 | 0.85 | SIRT2 (0.58) | SIRT2AKR1C3AKR1C2MAPTNPC1 | |
| SCHEMBL9409188 | 0.85 | SIRT2 (0.51) | SIRT2MAPTNPC1SMN1; SMN2RAB9A | |
| SCHEMBL9409084 | 0.84 | SIRT2 (0.73) | SIRT2AKR1C3AKR1C2MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600832-A1 | Derivatives of diamino benzoic and diamino phthalic acid und their use as protein linase inhibitors | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | claimed |
| EP-0600832-A1 | Derivatives of diamino benzoic and diamino phthalic acid und their use as protein linase inhibitors | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | disclosed |