Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088110 | 0.84 | SCN9A (0.39) | HSD11B1SCN9AP2RX7ALDH1A1 | |
| SCHEMBL4092189 | 0.83 | HSD11B1 (0.39) | HSD11B1SCN9AP2RX7 | |
| SCHEMBL4093078 | 0.76 | HSD11B1 (0.48) | HSD11B1 | |
| SCHEMBL4088360 | 0.71 | HSD11B1 (0.51) | HSD11B1 | |
| SCHEMBL4089235 | 0.69 | SCN9A (0.39) | HSD11B1SCN9AOPRK1 | |
| SCHEMBL4083612 | 0.67 | SCN9A (0.39) | HSD11B1SCN9AP2RX7ALDH1A1 | |
| SCHEMBL78488 | 0.67 | HSD11B1 (0.42) | HSD11B1ADAM17ALDH1A1 | |
| SCHEMBL328911 | 0.67 | HSD11B1 (0.49) | HSD11B1SCN9AALDH1A1LMNA | |
| SCHEMBL4084557 | 0.66 | SCN9A (0.39) | HSD11B1SCN9AALDH1A1 | |
| SCHEMBL2170311 | 0.66 | P2RX7 (0.40) | HSD11B1SCN9AP2RX7ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |