Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 12/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088360 | 0.88 | HSD11B1 (0.51) | HSD11B1HSD11B2 | |
| SCHEMBL4092563 | 0.84 | HSD11B1 (0.39) | SCN9AHSD11B1ALDH1A1P2RX7 | |
| SCHEMBL4092189 | 0.81 | HSD11B1 (0.39) | SCN9AHSD11B1P2RX7HSD11B2 | |
| SCHEMBL4083612 | 0.74 | SCN9A (0.39) | SCN9AHSD11B1ALDH1A1P2RX7DGAT1 | |
| SCHEMBL4093078 | 0.72 | HSD11B1 (0.48) | HSD11B1HSD11B2 | |
| SCHEMBL4084557 | 0.67 | SCN9A (0.39) | SCN9AHSD11B1ALDH1A1HSD11B2 | |
| SCHEMBL28839563 | 0.67 | DPP4 (0.40) | ALDH1A1DPP4DPP8DPP7 | |
| SCHEMBL4089235 | 0.67 | SCN9A (0.39) | SCN9AHSD11B1 | |
| SCHEMBL4089109 | 0.66 | HSD11B1 (0.39) | SCN9AHSD11B1ALDH1A1HSD11B2 | |
| SCHEMBL78488 | 0.66 | HSD11B1 (0.42) | HSD11B1ALDH1A1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |