Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 7/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.31 |
| ▸ | CBLB | Q13191 | 4/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088979 | 0.81 | L3MBTL1 (0.38) | ALDH1A1AADATTDP1L3MBTL1 | |
| SCHEMBL76185 | 0.68 | C5AR1 (0.35) | ALDH1A1P2RX7C5AR1PARP1 | |
| SCHEMBL23841329 | 0.66 | P2RX7 (0.39) | ALDH1A1P2RX7TDP1 | |
| SCHEMBL27760504 | 0.65 | C5AR1 (0.32) | P2RX7C5AR1 | |
| SCHEMBL16787389 | 0.65 | ALDH1A1 (0.43) | ALDH1A1P2RX7 | |
| SCHEMBL4084134 | 0.64 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1 | |
| SCHEMBL20355248 | 0.62 | P2RX7 (0.43) | ALDH1A1P2RX7 | |
| SCHEMBL4078586 | 0.61 | L3MBTL1 (0.43) | ALDH1A1AADATTDP1L3MBTL1 | |
| SCHEMBL10304749 | 0.61 | P2RX7 (0.42) | ALDH1A1P2RX7TDP1 | |
| SCHEMBL21283351 | 0.60 | GABRA1 (0.52) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | claimed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | claimed |
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |