Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100B | P04271 | 1/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 2/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL5495435 | 0.86 | S1PR1 (0.56) | S100BS1PR1ALDH1A1MAPTRAB9A | |
| SCHEMBL4300627 | 0.84 | S100B (0.67) | S100BS1PR1ALDH1A1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL10630977 | 0.82 | S100B (0.64) | S100BS1PR1ALDH1A1MAPTRAB9A | |
| SCHEMBL13412506 | 0.77 | S1PR1 (0.56) | S100BS1PR1ALDH1A1MAPTRAB9A | |
| SCHEMBL11580628 | 0.73 | S100B (0.53) | S100BS1PR1ALDH1A1MAPTRAB9A | |
| Tromethamine SCHEMBL5503175 | 0.73 | ALDH1A1 (0.64) | ALDH1A1MAPTRAB9ACYP3A4MAPK1 | |
| SCHEMBL6123711 | 0.72 | S100B (0.52) | S100BS1PR1ALDH1A1MAPTRAB9A | |
| SCHEMBL1417292 | 0.72 | S100B (0.61) | S100BS1PR1ALDH1A1MAPTRAB9A | |
| SCHEMBL3226363 | 0.71 | S100B (0.56) | S100BALDH1A1MAPTRAB9ACYP3A4 | |
| SCHEMBL21570286 | 0.71 | S1PR1 (0.50) | S100BS1PR1ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090212237-A1 | COMPOSITION FOR DETERMINATION OF IONIZING RADIATION ABSORBED DOSE AND USE THEREOF | SAKATA INX CORP. (JP) | 2009-08-27 | — | — | US | disclosed |
| EP-0222878-A4 | AQUEOUS ALKALINE DEVELOPABLE, UV CURABLE URETHANE ACRYLATE COMPOUNDS AND COMPOSITIONS USEFUL FOR FORMING SOLDER MASK COATINGS. | M & T CHEMICALS INC (US) | 1987-09-02 | — | — | EP | disclosed |
| EP-0222878-A1 | AQUEOUS ALKALINE DEVELOPABLE, UV CURABLE URETHANE ACRYLATE COMPOUNDS AND COMPOSITIONS USEFUL FOR FORMING SOLDER MASK COATINGS. | M & T CHEMICALS INC (US) | 1987-05-27 | — | — | EP | disclosed |
| WO-1986006730-A1 | AQUEOUS ALKALINE DEVELOPABLE, UV CURABLE URETHANE ACRYLATE COMPOUNDS AND COMPOSITIONS USEFUL FOR FORMING SOLDER MASK COATINGS | M&T CHEMICALS, INC. (US) | 1986-11-20 | — | — | WO | disclosed |