SCHEMBL4093282

SCHEMBL4093282

COc1ccc(C(=O)c2ccc(OCCc3ccc(OCc4ccccc4)cc3)nc2)c(OC(C)(C)C(=O)OC(=O)C(F)(F)F)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 6/20 0.40
CYP11B1 P15538 2/20 0.38
CYP11B2 P19099 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
MEN1 O00255 1/20 0.37
PABPC1 P11940 1/20 0.37
KMT2A Q03164 1/20 0.37
POLB P06746 2/20 0.36
APP P05067 1/20 0.36
PPARD Q03181 3/20 0.36
PPARA Q07869 3/20 0.36
NR1H2 P55055 1/20 0.36
NR1H3 Q13133 1/20 0.36
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CSNK2A2 P19784 1/20 0.35
CSNK2A1 P68400 1/20 0.35
MTNR1A P48039 1/20 0.35
MTNR1B P49286 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4103438 0.92 POLB (0.40) PPARGTDP1MEN1PABPC1KMT2A
Trifluoroacetic Acid SCHEMBL4093275 0.92 PPARG (0.47) PPARGCYP11B1CYP11B2TDP1PPARD
SCHEMBL4099606 0.89 PPARG (0.35) PPARGCYP11B1CYP11B2MEN1KMT2A
SCHEMBL4098190 0.88 LMNA (0.39) PPARGMEN1KMT2APOLBNPC1
SCHEMBL4099751 0.85 CYP11B1 (0.43) PPARGCYP11B1CYP11B2MEN1KMT2A
SCHEMBL4108540 0.85 KCNH2 (0.35) PPARGCYP11B1CYP11B2TDP1MEN1
SCHEMBL4103465 0.85 PPARG (0.50) PPARGCYP11B1CYP11B2POLBPPARD
SCHEMBL4105734 0.85 POLB (0.38) MEN1PABPC1KMT2APOLBNPC1
SCHEMBL4103730 0.84 NPC1 (0.38) TDP1MEN1KMT2APOLBNPC1
Trifluoroacetic Acid SCHEMBL4103434 0.83 PPARG (0.45) PPARGTDP1POLBPPARDPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090054435-A1 Phenoxyalkanoic Acid Compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-02-26 US disclosed
EP-1911738-A1 PHENOXYALKANOIC ACID COMPOUND Takeda Pharmaceutical Company Limited (JP) 2008-04-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090054435-A1 Phenoxyalkanoic Acid Compound PNLIP, GPR119, LIPC PPARG 23/4885CYP11B1 646/4885CYP11B2 1006/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.