Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 2/20 | 0.40 |
| ▸ | ATP4A | P20648 | 3/20 | 0.38 |
| ▸ | ATP4B | P51164 | 3/20 | 0.38 |
| ▸ | DDX3X | O00571 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2205225 | 0.70 | IMPDH2 (0.43) | IMPDH2CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL8314281 | 0.69 | RAB9A (0.47) | CYP1A2CYP2C9MEN1KMT2AMAPT | |
| SCHEMBL9561901 | 0.68 | CCR6 (0.56) | IMPDH2CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL17383846 | 0.68 | IMPDH2 (0.73) | IMPDH2CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL2204248 | 0.67 | MEN1 (0.46) | IMPDH2CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL31060312 | 0.66 | IMPDH2 (1.00) | IMPDH2CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL9572001 | 0.66 | PTPRC (0.50) | IMPDH2MEN1KMT2AMAPTLMNA | |
| SCHEMBL16169793 | 0.65 | IMPDH2 (0.69) | IMPDH2CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL20561846 | 0.65 | IMPDH2 (0.63) | IMPDH2CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL9562597 | 0.65 | PTPRC (0.59) | IMPDH2CCR6HKDC1GAAMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805171-A4 | INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | WYETH CORP (US) | 2009-05-13 | — | — | EP | disclosed |
| EP-1805171-A2 | INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | Athersys, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006034419-A2 | INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | ATHERSYS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |