SCHEMBL4094050

SCHEMBL4094050

CSc1ccc2oc(CBr)cc2c1

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
F2 P00734 1/20 0.36
F10 P00742 1/20 0.36
LOXL2 Q9Y4K0 1/20 0.34
ACHE P22303 1/20 0.34
CYP19A1 P11511 2/20 0.33
AGXT P21549 1/20 0.32
MAOA P21397 1/20 0.31
MAOB P27338 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4099049 0.82 HDAC6 (0.41) F2F10LOXL2ACHEMAOA
SCHEMBL11886576 0.78 MAOB (0.49) MAOAMAOB
SCHEMBL16376504 0.76 CYP19A1 (0.53) CYP19A1MAOA
SCHEMBL123488 0.74 CYP19A1 (0.51) CYP19A1MAOB
SCHEMBL123183 0.74 CA12 (0.42) F2F10LOXL2CYP19A1
SCHEMBL3617999 0.74 APP (0.38) F2F10LOXL2CYP19A1AGXT
SCHEMBL119314 0.74 CYP2A6 (0.51) MAOAMAOB
SCHEMBL18936000 0.72 ACHE (0.36) ACHEMAOAMAOB
SCHEMBL9825775 0.71 HDAC6 (0.35) LOXL2ACHECYP19A1AGXTMAOA
SCHEMBL119196 0.71 LOXL2 (0.64) LOXL2CYP19A1AGXTMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090221644-A1 Gpcr Agonists PROSIDION LIMITED (GB) 2009-09-03 US disclosed
EP-1907384-A2 GPCR AGONISTS Prosidion Limited (GB) 2008-04-09 EP disclosed
WO-2007003961-A2 GPCR AGONISTS PROSIDION LIMITED (GB) 2007-01-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090221644-A1 Gpcr Agonists GPR119, GCGR, GPR27 F2 4031/4885F10 4119/4885LOXL2 1472/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.