Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 4/20 | 0.39 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CPT2 | P23786 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL10561739 | 0.97 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28282255 | 0.95 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL673949 | 0.95 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL735448 | 0.95 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL5030701 | 0.95 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28259791 | 0.95 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL3766978 | 0.95 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL27673727 | 0.93 | ALDH1A1 (0.68) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL25332361 | 0.92 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL8647305 | 0.92 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114306271-B | Lunvatinib composition | 石药集团中奇制药技术（石家庄）有限公司 | 2023-04-07 | — | — | CN | claimed |
| CN-114306271-A | Lunvatinib composition | 石药集团中奇制药技术（石家庄）有限公司 | 2022-04-12 | — | — | CN | claimed |
| CN-114306271-B | Lunvatinib composition | 石药集团中奇制药技术（石家庄）有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-114306271-A | Lunvatinib composition | 石药集团中奇制药技术（石家庄）有限公司 | 2022-04-12 | — | — | CN | disclosed |
| US-20210230082-A1 | PLANT NUTRIENT COMPOSITIONS | NUTRIFIELD PTY LTD (AU) | 2021-07-29 | — | — | US | disclosed |
| EP-2050341-B1 | METHOD FOR PREPARING DELACTOSED MILK | SHANGHAI SHANGLONG DAIRY CO LTD (CN) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016022973-A1 | INSUFFLATION APPARATUS AND METHOD OF USE | ENDOINSIGHT, INC. (US) | 2016-02-11 | — | — | WO | disclosed |
| US-20140081169-A1 | SYSTEM AND METHOD OF TETHERLESS INSUFFLATION IN COLON CAPSULE ENDOSCOPY | VANDERBILT UNIVERSITY (US) | 2014-03-20 | — | — | US | disclosed |
| US-8580323-B2 | Method for making lactose removed milk | SHANGHAI SHANGLONG DAIRY CO., LTD. (CN) | 2013-11-12 | — | — | US | disclosed |
| US-20120207850-A1 | Methods for Increasing the Kinetic Activity of Alcohol, Water and Other Liquids, so as to Render the Liquids More Useful in Enhancing the Alternative Cellular Energy Pathway in the Prevention and Therapy of Diseases | MARTIN WILLIAM JOHN (US) | 2012-08-16 | — | — | US | disclosed |
| US-20120152755-A1 | Energy Charged Liquids to Enhance Enerceutical Activation of the Alternative Cellular Energy (ACE) Pathway in the Therapy of Diseases | MARTIN WILLIAM JOHN (US) | 2012-06-21 | — | — | US | disclosed |
| US-20090123602-A1 | METHOD FOR MAKING LACTOSE-REMOVING MILK | SHANGHAI SHANGLONG DAIRY CO.,LTD. (CN) | 2009-05-14 | — | — | US | disclosed |
| CN-101426375-A | Method for preparing sugar-removing milk | SHANGHAI SHANGLONG MILK CO LTD (CN) | 2009-05-06 | — | — | CN | disclosed |
| EP-2050341-A1 | METHOD FOR MAKING LACTOSE-REMOVING MILK | Shanghai Shanglong Dairy Co., Ltd. (CN) | 2009-04-22 | — | — | EP | disclosed |
| US-4820870-A | FOR REMOVAL AND/OR PREVENTION OF URINARY TRACT STONES; SODIUM-POTASSIUM-HYDROGEN SALTS OF CITRIC ACID | DR. MADAUS & CO. (DE) | 1989-04-11 | — | — | US | disclosed |