Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | CASP1 | P29466 | 3/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | HTR1B | P28222 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021582 | 0.94 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL4094478 | 0.74 | MAPT (0.42) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL4094483 | 0.72 | CASP1 (0.58) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2021575 | 0.72 | MAPT (0.43) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2044381 | 0.69 | HSD17B10 (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2044387 | 0.68 | HSD17B10 (0.46) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2050348 | 0.68 | HSD17B10 (0.46) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2021578 | 0.66 | SMN1; SMN2 (0.61) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3687749 | 0.65 | MAPT (0.63) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2020896 | 0.63 | HTR1B (0.44) | MEN1KMT2AALDH1A1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062251-A1 | Novel Compounds 002 | ASTRAZENECA AB (SE) | 2009-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062251-A1 | Novel Compounds 002 | OPRL1, OPRK1, OPRM1 | SMN1; SMN2 129/4885MEN1 3055/4885KMT2A 2567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.