Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HK1 | P19367 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4095742 | 0.80 | BRD4 (0.40) | ALDH1A1SMN1; SMN2KDM4EHTTLMNA | |
| SCHEMBL4084945 | 0.76 | DYRK1A (0.41) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL13885188 | 0.71 | JAK3 (0.38) | KCNH2 | |
| SCHEMBL30605772 | 0.68 | MAPT (0.49) | KCNH2ALDH1A1SMN1; SMN2KDM4EHTT | |
| SCHEMBL1998027 | 0.68 | MAPT (0.49) | KCNH2ALDH1A1SMN1; SMN2KDM4EHTT | |
| SCHEMBL2599810 | 0.68 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KDM4EHTTLMNA | |
| SCHEMBL4094763 | 0.68 | PDE4B (0.32) | ALDH1A1CYP1A2 | |
| SCHEMBL5676525 | 0.66 | KCNH2 (0.43) | KCNH2ALDH1A1SMN1; SMN2HK1HKDC1 | |
| SCHEMBL20838602 | 0.66 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2HK1HKDC1KDM4E | |
| SCHEMBL29426296 | 0.66 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2HK1HKDC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009055674-A1 | PYRROLOPYRIMIDINE ALKYNYL COMPOUNDS AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009055674-A1 | PYRROLOPYRIMIDINE ALKYNYL COMPOUNDS AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-04-30 | — | — | WO | disclosed |