Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780980 | 0.79 | METAP2 (0.42) | ALDH1A1HSD17B10TGFBR1PIM1SCN4A | |
| SCHEMBL15288191 | 0.76 | PLK4 (0.36) | ALDH1A1PIM1PIM3MEN1KMT2A | |
| SCHEMBL21692150 | 0.76 | PTGS1 (0.58) | PTGS2PTGS1FEN1ALDH1A1HTT | |
| SCHEMBL10018 | 0.74 | SCN4A (0.46) | ALDH1A1HPGDSSCN4ANPY5R | |
| SCHEMBL12854120 | 0.74 | PTPRC (0.57) | PTGS2PTGS1FEN1ALDH1A1HTT | |
| SCHEMBL37278 | 0.74 | PTGS2 (0.66) | PTGS2PTGS1FEN1ALDH1A1HTT | |
| Ammonia Solution, Strong SCHEMBL20599554 | 0.73 | PTGS2 (0.64) | PTGS2PTGS1FEN1ALDH1A1HTT | |
| SCHEMBL30021842 | 0.73 | PTGS2 (0.64) | PTGS2PTGS1FEN1ALDH1A1HTT | |
| Phosphine SCHEMBL29108837 | 0.73 | PTGS2 (0.64) | PTGS2PTGS1FEN1ALDH1A1HTT | |
| SCHEMBL29227428 | 0.73 | PTGS2 (0.64) | PTGS2PTGS1FEN1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059250-A2 | COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS | Synta Pharmaceuticals Corporation (US) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008033449-A2 | COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS | SYNTA PHARMACEUTICALS CORP. (US) | 2008-03-20 | — | — | WO | disclosed |