Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28249200 | 0.79 | KDM4E (0.47) | OPRM1OPRL1AKR1C1OPRK1RXRA | |
| SCHEMBL3408517 | 0.77 | MAPT (0.38) | OPRM1SLC6A2SLC6A4SLC6A3RXRA | |
| SCHEMBL8486337 | 0.77 | L3MBTL1 (0.49) | OPRM1OPRK1SLC6A4MEN1KMT2A | |
| SCHEMBL8486339 | 0.77 | L3MBTL1 (0.49) | OPRM1OPRK1SLC6A4MEN1KMT2A | |
| SCHEMBL8484165 | 0.75 | L3MBTL1 (0.50) | OPRM1OPRK1SLC6A4MEN1KMT2A | |
| SCHEMBL8484168 | 0.75 | L3MBTL1 (0.50) | OPRM1OPRK1SLC6A4MEN1KMT2A | |
| SCHEMBL2437925 | 0.74 | OPRM1 (0.46) | OPRM1OPRL1AKR1C1OPRK1RXRA | |
| SCHEMBL5197233 | 0.70 | AKR1C1 (0.40) | OPRM1AKR1C1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1334112 | 0.70 | AKR1C1 (0.44) | OPRM1OPRL1AKR1C1HDAC4MEN1 | |
| SCHEMBL1334113 | 0.70 | AKR1C1 (0.44) | OPRM1OPRL1AKR1C1HDAC4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962834-B2 | Modulators of amyloid beta | HOFFMANN-LA ROCHE INC. (US) | 2015-02-24 | — | — | US | disclosed |
| EP-2257541-B1 | MODULATORS FOR AMYLOID BETA | HOFFMANN LA ROCHE (CH) | 2013-08-14 | — | — | EP | disclosed |
| US-20130190302-A1 | MODULATORS OF AMYLOID BETA | HOFFMANN-LA ROCHE INC. (US) | 2013-07-25 | — | — | US | disclosed |
| US-20090215759-A1 | MODULATORS FOR AMYLOID BETA | HOFFMANN-LA ROCHE, INC. | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215759-A1 | MODULATORS FOR AMYLOID BETA | APP, PSEN1, APOB | OPRM1 2868/4885OPRL1 1241/4885AKR1C1 3383/4885 |
| US-20130190302-A1 | MODULATORS OF AMYLOID BETA | APP, PSEN1, APOB | OPRM1 2857/4885OPRL1 1214/4885AKR1C1 3420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.