Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 2/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | RAD51 | Q06609 | 3/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4090666 | 0.81 | TGFBR1 (0.36) | PDE10AMAP4K4MINK1TNIK | |
| SCHEMBL4098176 | 0.76 | ADORA2B (0.49) | ADORA2BNQO2ADORA2APDE2APDE10A | |
| SCHEMBL4101340 | 0.72 | BRAF (0.52) | ADORA2BNQO2ADORA2APDE2APDE10A | |
| SCHEMBL30066479 | 0.71 | CYP2A6 (0.58) | ADORA2BNQO2ADORA2APDE2APDE10A | |
| SCHEMBL13741474 | 0.65 | ADORA2B (0.51) | ADORA2BNQO2ADORA2AMAP4K4MINK1 | |
| SCHEMBL4090706 | 0.65 | ADORA2B (0.57) | ADORA2BNQO2ADORA2AMAP4K4MINK1 | |
| SCHEMBL6222836 | 0.65 | TGFBR1 (0.40) | MAPK14 | |
| SCHEMBL12137676 | 0.64 | ADORA2B (0.59) | ADORA2BNQO2ADORA2APDE2APDE10A | |
| SCHEMBL10220715 | 0.62 | KIF11 (0.54) | CYP2A6KIF11CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL16132299 | 0.60 | CYP2A6 (0.61) | CYP2A6KIF11CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | INCYTE CORPORATION | 2006-05-18 | — | — | US | disclosed |
| WO-2005105814-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | JAK1, JAK2, JAK3 | ADORA2B 4778/4885NQO2 3554/4885ADORA2A 4577/4885 |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | JAK1, JAK2, JAK3 | ADORA2B 4778/4885NQO2 3554/4885ADORA2A 4577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.