Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MARS2 | Q96GW9 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.36 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.36 |
| ▸ | RPS17 | P08708 | 1/20 | 0.36 |
| ▸ | RPSA | P08865 | 1/20 | 0.36 |
| ▸ | RPS2 | P15880 | 1/20 | 0.36 |
| ▸ | RPL35A | P18077 | 1/20 | 0.36 |
| ▸ | RPL7 | P18124 | 1/20 | 0.36 |
| ▸ | RPL17 | P18621 | 1/20 | 0.36 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.36 |
| ▸ | RPS3 | P23396 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9906223 | 0.80 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2LMNATSHRCYP2C19 | |
| Alcohol SCHEMBL4097978 | 0.76 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2LMNATSHRKDM4E | |
| SCHEMBL8933772 | 0.72 | SIGMAR1 (0.52) | ALDH1A1SMN1; SMN2LMNAKDM4EMAPT | |
| SCHEMBL19157365 | 0.72 | ADRB2 (0.39) | ALDH1A1CYP3A4SMN1; SMN2LMNATSHR | |
| SCHEMBL2374452 | 0.71 | ALDH1A1 (0.57) | ALDH1A1CYP3A4SMN1; SMN2LMNAMARS2 | |
| SCHEMBL7263803 | 0.68 | ALDH1A1 (0.53) | ALDH1A1CYP3A4SMN1; SMN2LMNAMARS2 | |
| SCHEMBL8543345 | 0.67 | TSHR (0.50) | ALDH1A1SMN1; SMN2LMNATSHRCYP2C19 | |
| SCHEMBL1299034 | 0.65 | ALDH1A1 (0.49) | ALDH1A1KDM4ENPC1MAPTMEN1 | |
| SCHEMBL651374 | 0.65 | ALDH1A1 (0.49) | ALDH1A1KDM4ENPC1MAPTMEN1 | |
| SCHEMBL28592383 | 0.65 | ALDH1A1 (0.49) | ALDH1A1KDM4ENPC1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004642-B1 | BIFUNCTIONAL POLYAZAMACROCYCLIC CHELATING AGENTS | Nordion (Canada) Inc (CA) | 2017-07-26 | — | — | EP | disclosed |
| US-8518715-B2 | Bifunctional polyazamacrocyclic chelating agents | NORDION (CANADA) INC. (CA) | 2013-08-27 | — | — | US | disclosed |
| US-20120276001-A1 | BIFUNCTIONAL POLYAZAMACROCYCLIC CHELATING AGENTS | Nordion (Canada) Inc (CA) | 2012-11-01 | — | — | US | disclosed |
| US-8198101-B2 | Bifunctional polyazamacrocyclic chelating agents | NORDION (CANADA) INC. (CA) | 2012-06-12 | — | — | US | disclosed |
| US-20090202521-A1 | Bifunctional Polyazamacrocyclic Chelating Agents | MDS (CANADA) INC. (CA) | 2009-08-13 | — | — | US | disclosed |
| EP-2004642-A1 | BIFUNCTIONAL POLYAZAMACROCYCLIC CHELATING AGENTS | MDS (Canada) Inc. (CA) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007104135-A1 | BIFUNCTIONAL POLYAZAMACROCYCLIC CHELATING AGENTS | MDS (CANADA) INC. (CA) | 2007-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090202521-A1 | Bifunctional Polyazamacrocyclic Chelating Agents | LPXN, FCGRT, POLQ | ALDH1A1 2764/4885CYP3A4 4555/4885SMN1; SMN2 2301/4885 |
| US-20120276001-A1 | BIFUNCTIONAL POLYAZAMACROCYCLIC CHELATING AGENTS | LPXN, FCGRT, F13A1 | ALDH1A1 2824/4885CYP3A4 4568/4885SMN1; SMN2 2145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.