Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfadiazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.96 |
| ▸ | AURKA | O14965 | 1/20 | 0.96 |
| ▸ | DHFR | P00374 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 1/20 | 0.96 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | EDNRA | P25101 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfadiazine SCHEMBL3274530 | 1.00 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL16860643 | 1.00 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL34517 | 1.00 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL27795518 | 0.98 | LMNA (0.93) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL18668477 | 0.98 | LMNA (0.93) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL10422849 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL24176 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL30080807 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL5870705 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL6141086 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160151533-A1 | COMPOSITIONS FOR TREATING BIOFILMS AND METHODS FOR USING SAME | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT | 2016-06-02 | — | — | US | claimed |
| US-20130101661-A1 | COMPOSITIONS FOR TREATING BIOFILMS AND METHODS FOR USING SAME | PLUROGEN THERAPEUTICS, INC. (US) | 2013-04-25 | — | — | US | claimed |
| EP-2120561-A1 | COMPOSITIONS FOR TREATING BIOFILMS AND METHODS FOR USING SAME | Plurogen Therapeutics, Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| US-20090202615-A1 | Compositions for Treating Biofilms and Methods for Using Same | PLUROGEN THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | US | claimed |
| WO-2008103673-A1 | COMPOSITIONS FOR TREATING BIOFILMS AND METHODS FOR USING SAME | PLUROGEN THERAPEUTICS, INC. (US) | 2008-08-28 | — | — | WO | claimed |
| CN-112890310-A | Antibacterial underpants and preparation method thereof | 泉州市锦恒服装实业有限公司 | 2021-06-04 | — | — | CN | disclosed |
| US-20190008993-A1 | Compositions for Treating Biofilms and Methods for Using Same | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT | 2019-01-10 | — | — | US | disclosed |
| CN-108478843-A | With the medical dressing and preparation method thereof containing copper coating | 中国科学院金属研究所 | 2018-09-04 | — | — | CN | disclosed |
| US-9884136-B2 | Compositions for treating biofilms and methods for using same | PLUROGEN THERAPEUTICS, INC. (US) | 2018-02-06 | — | — | US | disclosed |
| US-20170216480-A1 | COMPOSITIONS FOR TREATING BIOFILMS AND METHODS FOR USING SAME | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT | 2017-08-03 | — | — | US | disclosed |
| EP-3170396-A1 | COMPOSITIONS FOR TREATING BIOFILMS AND METHODS FOR USING SAME | Plurogen Therapeutics, Inc. (US) | 2017-05-24 | — | — | EP | disclosed |
| US-9603966-B2 | Compositions for treating biofilms and methods for using same | PLUROGEN THERAPEUTICS, INC. (US) | 2017-03-28 | — | — | US | disclosed |
| US-20160151533-A1 | COMPOSITIONS FOR TREATING BIOFILMS AND METHODS FOR USING SAME | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT | 2016-06-02 | — | — | US | disclosed |
| US-9283278-B2 | Compositions for treating biofilms and methods for using same | PLUROGEN THERAPEUTICS, INC. (US) | 2016-03-15 | — | — | US | disclosed |
| US-20150099009-A1 | COMPOSITIONS FOR TREATING BIOFILMS AND METHODS FOR USING SAME | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT | 2015-04-09 | — | — | US | disclosed |
| US-8871248-B2 | Compositions for treating biofilms and methods for using same | PLUROGEN THERAPEUTICS, INC. (US) | 2014-10-28 | — | — | US | disclosed |
| US-20130101661-A1 | COMPOSITIONS FOR TREATING BIOFILMS AND METHODS FOR USING SAME | PLUROGEN THERAPEUTICS, INC. (US) | 2013-04-25 | — | — | US | disclosed |
| EP-2120561-A1 | COMPOSITIONS FOR TREATING BIOFILMS AND METHODS FOR USING SAME | Plurogen Therapeutics, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20090202615-A1 | Compositions for Treating Biofilms and Methods for Using Same | PLUROGEN THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | US | disclosed |
| WO-2008103673-A1 | COMPOSITIONS FOR TREATING BIOFILMS AND METHODS FOR USING SAME | PLUROGEN THERAPEUTICS, INC. (US) | 2008-08-28 | — | — | WO | disclosed |