Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 4/20 | 0.37 |
| ▸ | MAP2 | P11137 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4098612 | 0.71 | HPGD (0.39) | MEN1ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL5658472 | 0.71 | MAOB (0.39) | CYP1A2ACHEMAOBMAOA | |
| SCHEMBL5657363 | 0.69 | KDM4E (0.41) | ERN1CYP1A2MEN1ALDH1A1MAPT | |
| SCHEMBL5657857 | 0.69 | MAOB (0.38) | STK17BACHEMEN1ALDH1A1MAPT | |
| SCHEMBL4107175 | 0.66 | KDM4E (0.44) | MEN1ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL5659868 | 0.66 | KIF11 (0.33) | — | |
| SCHEMBL5668839 | 0.65 | KIF11 (0.34) | MAOBMAPK1MAOA | |
| SCHEMBL5798969 | 0.62 | ALDH1A1 (0.43) | STK17BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL15348507 | 0.61 | ERN1 (0.58) | ERN1CYP1A2ALDH1A1MAPTKDM4E | |
| SCHEMBL15759795 | 0.59 | APP (0.46) | NR3C1MEN1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221687-A1 | Tetracyclic Monoamine Reuptake Inhibitors for Treatment of Cns Diseases and Disorders | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB (HR) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221687-A1 | Tetracyclic Monoamine Reuptake Inhibitors for Treatment of Cns Diseases and Disorders | MAOB, MAOA, TPH1 | STK17B 2322/4885HDAC3 1390/4885HDAC4 1115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.