Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | AHR | P35869 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2735412 | 0.78 | RAB9A (0.56) | MAPTSMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL213628 | 0.78 | RAB9A (0.56) | MAPTSMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL217226 | 0.77 | MEN1 (0.48) | MAPTSMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL2759942 | 0.74 | NPC1 (0.54) | MAPTSMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL214402 | 0.74 | SMN1; SMN2 (0.46) | MAPTSMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL2735324 | 0.71 | ALDH1A1 (0.56) | MAPTSMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL4105577 | 0.71 | GAA (0.55) | MAPTSMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL216491 | 0.70 | NTRK1 (0.47) | MAPTSMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL25028319 | 0.70 | SIRT1 (0.60) | MAPTSMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL12659646 | 0.69 | THRB (0.50) | MAPTSMN1; SMN2NPC1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061768-A2 | IMIDAZOLE-4,5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | Exelixis, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008042282-A2 | IMIDAZOLE-4, 5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | EXELIXIS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |