Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1410630 | 1.00 | LMNA (0.35) | LMNAACE2 | |
| SCHEMBL17143627 | 1.00 | LMNA (0.35) | LMNAACE2 | |
| SCHEMBL15326957 | 0.98 | ACE2 (0.35) | LMNAACE2 | |
| SCHEMBL8811887 | 0.98 | ACE2 (0.35) | LMNAACE2 | |
| SCHEMBL4575538 | 0.98 | ACE2 (0.35) | LMNAACE2 | |
| SCHEMBL4979534 | 0.98 | ACE2 (0.35) | LMNAACE2 | |
| SCHEMBL15326983 | 0.98 | ACE2 (0.35) | LMNAACE2 | |
| SCHEMBL1410664 | 0.98 | ACE2 (0.35) | LMNAACE2 | |
| SCHEMBL2431181 | 0.98 | ACE2 (0.35) | LMNAACE2 | |
| SCHEMBL294759 | 0.98 | ACE2 (0.35) | LMNAACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10711040-B2 | Low substituted polymyxins and compositions thereof | XELLIA PHARMACEUTICALS APS (DK) | 2020-07-14 | — | — | US | claimed |
| US-10640536-B2 | Polymyxins, compositions, methods of making and methods of use | XELLIA PHARMACEUTICALS APS (DK) | 2020-05-05 | — | — | US | claimed |
| EP-3166960-B1 | LOW SUBSTITUTED POLYMYXINS AND COMPOSITIONS THEREOF | XELLIA PHARMACEUTICALS APS (DK) | 2019-08-07 | — | — | EP | claimed |
| EP-2943503-B1 | POLYMYXINS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE | XELLIA PHARMACEUTICALS APS (DK) | 2017-08-23 | — | — | EP | claimed |
| US-20170218024-A1 | LOW SUBSTITUTED POLYMYXINS AND COMPOSITIONS THEREOF | XELLIA PHARMACEUTICALS APS (DK) | 2017-08-03 | — | — | US | claimed |
| US-20170137469-A1 | POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS | MONASH UNIVERSITY (AU) | 2017-05-18 | — | — | US | claimed |
| EP-3166960-A1 | LOW SUBSTITUTED POLYMYXINS AND COMPOSITIONS THEREOF | Xellia Pharmaceuticals ApS (DK) | 2017-05-17 | — | — | EP | claimed |
| CN-106414480-A | POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS | 莫纳什大学 | 2017-02-15 | — | — | CN | claimed |
| EP-3126376-A1 | POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS | Monash University (AU) | 2017-02-08 | — | — | EP | claimed |
| WO-2016005223-A1 | LOW SUBSTITUTED POLYMYXINS AND COMPOSITIONS THEREOF | XELLIA PHARMACEUTICALS APS (DK) | 2016-01-14 | — | — | WO | claimed |
| US-20160002296-A1 | POLYMYXINS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE | XELLIA PHARMACEUTICALS APS (DK) | 2016-01-07 | — | — | US | claimed |
| EP-2943503-A1 | POLYMYXINS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE | Xellia Pharmaceuticals ApS (DK) | 2015-11-18 | — | — | EP | claimed |
| WO-2015149131-A1 | POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS | MONASH UNIVERSITY (AU) | 2015-10-08 | — | — | WO | claimed |
| CN-104918951-A | POLYMYXINS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE | XELLIA PHARMACEUTICALS APS | 2015-09-16 | — | — | CN | claimed |
| WO-2014108469-A1 | POLYMYXINS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE | XELLIA PHARMACEUTICALS APS (DK) | 2014-07-17 | — | — | WO | claimed |
| US-20090215677-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS LTD. (FI) | 2009-08-27 | — | — | US | claimed |
| US-20230131376-A1 | ADJUVANT-ANTIBIOTIC COMBINATION AGAINST GRAM-NEGATIVE BACTERIA | UNIVERSITY OF NOTRE DAME DU LAC | 2023-04-27 | — | — | US | disclosed |
| CN-114791470-A | Method for detecting polymyxin in blood by high performance liquid chromatography-tandem mass spectrometry and application | 北京和合医学诊断技术股份有限公司 | 2022-07-26 | — | — | CN | disclosed |
| US-8329645-B2 | Polymyxin derivatives and uses thereof | NORTHERN ANTIBIOTICS LTD. (FI) | 2012-12-11 | — | — | US | disclosed |
| US-20090215677-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS LTD. (FI) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215677-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | C5, C9, C3AR1 | LMNA 3052/4885ACE2 2482/4885 |
| US-20160002296-A1 | POLYMYXINS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE | C5, SGMS1, SGMS2 | LMNA 1985/4885ACE2 2724/4885 |
| US-20230131376-A1 | ADJUVANT-ANTIBIOTIC COMBINATION AGAINST GRAM-NEGATIVE BACTERIA | TLR4, TLR5, TLR1 | LMNA 1078/4885ACE2 595/4885 |
| US-10640536-B2 | Polymyxins, compositions, methods of making and methods of use | C5, HRH3, SGMS1 | LMNA 1993/4885ACE2 2782/4885 |
| US-20170218024-A1 | LOW SUBSTITUTED POLYMYXINS AND COMPOSITIONS THEREOF | TLR3, TLR4, TLR5 | LMNA 1175/4885ACE2 2804/4885 |
| US-10711040-B2 | Low substituted polymyxins and compositions thereof | TLR3, TLR4, TLR5 | LMNA 1175/4885ACE2 2804/4885 |
| US-20170137469-A1 | POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS | VIP, PEPD, NRDC | LMNA 2991/4885ACE2 2139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.