Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 11/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 11/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400871 | 0.82 | OPRL1 (0.46) | OPRM1OPRL1 | |
| SCHEMBL3404548 | 0.74 | HTR2A (0.41) | OPRM1OPRL1 | |
| SCHEMBL3402434 | 0.72 | — | — | |
| SCHEMBL3406577 | 0.71 | OPRM1 (0.33) | OPRM1OPRL1 | |
| SCHEMBL3404553 | 0.70 | — | — | |
| SCHEMBL4094812 | 0.70 | — | — | |
| SCHEMBL21766654 | 0.69 | OPRM1 (0.52) | OPRM1OPRL1LMNATSHR | |
| SCHEMBL3408958 | 0.68 | SIGMAR1 (0.39) | OPRM1 | |
| SCHEMBL3400838 | 0.68 | — | — | |
| SCHEMBL3404617 | 0.68 | OPRM1 (0.35) | OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254864-B1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2014-05-14 | — | — | EP | disclosed |
| US-20090215725-A1 | Substituted 4-aminocyclohexane derivatives | GRUNENTHAL GMBH (DE) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215725-A1 | Substituted 4-aminocyclohexane derivatives | OPRL1, OPRD1, OPRK1 | OPRM1 7/4885OPRL1 1/4885LMNA 2312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.