Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | SMARCA2 | P51531 | 6/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 5/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3000300 | 0.95 | FAAH (0.43) | FAAHSMARCA2SMARCA4EPHX2ALDH1A1 | |
| SCHEMBL3004476 | 0.94 | FAAH (0.53) | FAAHSMARCA2SMARCA4EPHX2NR2E1 | |
| SCHEMBL4083926 | 0.93 | LMNA (0.41) | FAAHSMARCA2SMARCA4EPHX2ALDH1A1 | |
| SCHEMBL3006995 | 0.92 | FAAH (0.48) | FAAHSMARCA2SMARCA4ALDH1A1LMNA | |
| SCHEMBL4100722 | 0.91 | FAAH (0.47) | FAAHSMARCA2SMARCA4EPHX2ALDH1A1 | |
| SCHEMBL2999781 | 0.91 | FAAH (0.43) | FAAHSMARCA2SMARCA4EPHX2ALDH1A1 | |
| SCHEMBL3008471 | 0.90 | TYK2 (0.42) | FAAHEPHX2ALDH1A1LMNAMAPT | |
| SCHEMBL3108612 | 0.90 | FAAH (0.55) | FAAHSMARCA2SMARCA4MAPTIDO1 | |
| SCHEMBL4384201 | 0.88 | FAAH (0.53) | FAAHSMARCA2SMARCA4EPHX2ALDH1A1 | |
| SCHEMBL4083369 | 0.88 | FAAH (0.48) | FAAHSMARCA2SMARCA4ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8884020-B2 | Indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| US-20090118503-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. | 2009-05-07 | — | — | US | disclosed |
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118503-A1 | FAAH INHIBITORS | FAAH, FAAH2, CNR2 | FAAH 1/4885SMARCA2 3375/4885SMARCA4 3200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.