SCHEMBL410106

SCHEMBL410106

CC(C)(C)OC(=O)c1ccc(NCC2=CC(=O)C=CC2=O)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.47
CA1 P00915 5/20 0.43
CA2 P00918 5/20 0.43
EGFR P00533 1/20 0.41
SETD7 Q8WTS6 2/20 0.41
STAT3 P40763 2/20 0.37
ABCG2 Q9UNQ0 1/20 0.37
CA12 O43570 1/20 0.37
CA9 Q16790 1/20 0.37
CA14 Q9ULX7 1/20 0.37
HKDC1 Q2TB90 1/20 0.37
POLB P06746 1/20 0.36
NPC1 O15118 2/20 0.36
ALDH1A1 P00352 2/20 0.36
RAB9A P51151 2/20 0.36
MAPT P10636 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
ALOX5 P09917 1/20 0.35
HPGD P15428 1/20 0.35
AGTR1 P30556 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL412798 0.87 CYP19A1 (0.61) CYP19A1CA1CA2SETD7HKDC1
SCHEMBL411958 0.82 HSP90AA1 (0.53) CYP19A1CA1CA2SETD7CA12
SCHEMBL23619645 0.74 CA1 (0.47) CA1CA2EGFRSTAT3ABCG2
SCHEMBL1711035 0.74 CA1 (0.73) CA1CA2ABCG2CA12CA14
SCHEMBL414361 0.74 CKS1B (0.58) CYP19A1CA1CA2EGFRSETD7
SCHEMBL1206152 0.73 CA1 (0.49) CA1CA2EGFRSTAT3ABCG2
SCHEMBL1711043 0.72 HDAC1 (0.59) CA1CA2POLBNPC1ALDH1A1
SCHEMBL17308777 0.72 CA1 (0.80) CA1CA2NPC1ALDH1A1RAB9A
SCHEMBL22661373 0.72 POLB (0.50) CA1CA2STAT3ABCG2CA12
SCHEMBL2338862 0.72 ALDH1A1 (0.48) CA1CA2EGFRSTAT3ABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120021519-A1 EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) 2012-01-26 US disclosed
WO-2010033906-A2 EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2010-03-25 WO disclosed