Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 5/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL412798 | 0.87 | CYP19A1 (0.61) | CYP19A1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL412892 | 0.82 | HSP90AA1 (0.38) | HSP90AA1CYP19A1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL410106 | 0.82 | CYP19A1 (0.47) | CYP19A1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL414361 | 0.74 | CKS1B (0.58) | HSP90AA1CYP19A1ALDH1A1LMNAHTT | |
| SCHEMBL412797 | 0.71 | ALDH1A1 (0.38) | CYP19A1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL701832 | 0.70 | CA12 (0.83) | HSP90AA1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL29020376 | 0.70 | LMNA (0.59) | HSP90AA1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL28307864 | 0.69 | CA12 (0.63) | HSP90AA1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL28761675 | 0.68 | CA12 (0.79) | HSP90AA1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL27667912 | 0.68 | CA12 (0.79) | HSP90AA1NPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |