Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 4/20 | 0.55 |
| ▸ | CA2 | P00918 | 4/20 | 0.55 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.55 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411958 | 0.87 | HSP90AA1 (0.53) | CYP19A1CA1CA2SETD7HKDC1 | |
| SCHEMBL410106 | 0.87 | CYP19A1 (0.47) | CYP19A1CA1CA2SETD7HKDC1 | |
| SCHEMBL414361 | 0.78 | CKS1B (0.58) | CYP19A1CA1CA2SETD7ALDH1A1 | |
| SCHEMBL413751 | 0.76 | CYP19A1 (1.00) | CYP19A1CA1CA2HKDC1POLB | |
| SCHEMBL412797 | 0.75 | ALDH1A1 (0.38) | CYP19A1POLBALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL13934091 | 0.75 | CA1 (0.87) | CYP19A1CA1CA2HKDC1POLB | |
| SCHEMBL25046258 | 0.72 | POLB (0.66) | CA1CA2HKDC1POLBALDH1A1 | |
| SCHEMBL1798924 | 0.71 | POLB (0.64) | CA1CA2HKDC1POLBALDH1A1 | |
| SCHEMBL20711646 | 0.71 | SETD7 (0.62) | CA1CA2SETD7ALDH1A1RAB9A | |
| SCHEMBL18415526 | 0.71 | CA1 (1.00) | CYP19A1CA1CA2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |