Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030436 | 0.94 | S1PR1 (0.41) | S1PR1S1PR5HPGDTP53MAPT | |
| SCHEMBL4106837 | 0.89 | HPGD (0.47) | MEN1KMT2AHPGDTP53MAPT | |
| SCHEMBL4116626 | 0.88 | CNR1 (0.42) | MEN1KMT2ATP53MAPT | |
| SCHEMBL4102629 | 0.87 | LMNA (0.44) | MEN1KMT2ATP53 | |
| SCHEMBL4118046 | 0.82 | HPGD (0.47) | HPGDTP53 | |
| SCHEMBL2637874 | 0.81 | PKM (0.47) | S1PR1S1PR5PKMMEN1KMT2A | |
| SCHEMBL1033418 | 0.81 | CNR2 (0.47) | HPGD | |
| SCHEMBL4106296 | 0.80 | KDM4E (0.44) | PKMMEN1KMT2AHPGDMAPT | |
| SCHEMBL4109233 | 0.78 | SMN1; SMN2 (0.45) | MEN1KMT2ATP53MAPT | |
| SCHEMBL4096188 | 0.77 | ICMT (0.38) | MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-A1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | Grünenthal GmbH (DE) | 2009-03-18 | — | — | EP | claimed |
| WO-2007141039-A1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | Grünenthal GmbH (DE) | 2007-12-13 | — | — | WO | claimed |
| EP-2035375-A1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | Grünenthal GmbH (DE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007141039-A1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | Grünenthal GmbH (DE) | 2007-12-13 | — | — | WO | disclosed |