Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15438142 | 0.82 | TSHR (0.50) | TSHRPPARDTP53TDP1CA12 | |
| SCHEMBL8764430 | 0.80 | ALDH1A1 (0.50) | TSHRPPARDTP53TDP1CA12 | |
| SCHEMBL15438473 | 0.78 | ALDH1A1 (0.56) | TSHRPPARDTP53TDP1CA12 | |
| SCHEMBL15438320 | 0.78 | TSHR (0.46) | TSHRPPARDTP53TDP1CA12 | |
| SCHEMBL15438226 | 0.78 | TSHR (0.46) | TSHRPPARDTP53TDP1ALDH1A1 | |
| SCHEMBL11663536 | 0.78 | TSHR (0.58) | TSHRPPARDTP53TDP1CA12 | |
| SCHEMBL15438833 | 0.77 | TSHR (0.44) | TSHRPPARDTP53TDP1CA12 | |
| SCHEMBL15439927 | 0.77 | TSHR (0.44) | TSHRPPARDTP53TDP1CA12 | |
| SCHEMBL7709958 | 0.76 | TSHR (0.40) | TSHRPPARDTP53TDP1CA12 | |
| SCHEMBL15438312 | 0.75 | TSHR (0.43) | TSHRPPARDALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4077964-A | FLAME RETARDANTS FOR POLYURETHANE FOAMS | SOCIETE NATIONALE DES POUDRES ET EXPLOSIFS (FR) | 1978-03-07 | — | — | US | claimed |
| US-20090131372-A1 | PHOSPHONATE ANALOGS FOR TREATING METABOLIC DISEASES | CHEN JAMES M | 2009-05-21 | — | — | US | disclosed |
| US-7407965-B2 | Phosphonate analogs for treating metabolic diseases | GILEAD SCIENCES, INC. (US) | 2008-08-05 | — | — | US | disclosed |
| US-20050227947-A1 | Phosphonate analogs for treating metabolic diseases | GILEAD SCIENCES, INC. | 2005-10-13 | — | — | US | disclosed |
| WO-2004096237-A2 | PHOSPHONATE ANALOGS FOR TREATING METABOLIC DISEASES | GILEAD SCIENCES, INC. (US) | 2004-11-11 | — | — | WO | disclosed |
| US-4113671-A | Carbamate-phosphonates as flame-proofing agents in polyurethane foam | SOCIETE NATIONALE DES POUDRES ET EXPLOSIFS (FR) | 1978-09-12 | — | — | US | disclosed |
| US-4113671-A | Carbamate-phosphonates as flame-proofing agents in polyurethane foam | SOCIETE NATIONALE DES POUDRES ET EXPLOSIFS (FR) | 1978-09-12 | — | — | US | disclosed |
| US-4077964-A | FLAME RETARDANTS FOR POLYURETHANE FOAMS | SOCIETE NATIONALE DES POUDRES ET EXPLOSIFS (FR) | 1978-03-07 | — | — | US | disclosed |
| US-4077964-A | FLAME RETARDANTS FOR POLYURETHANE FOAMS | SOCIETE NATIONALE DES POUDRES ET EXPLOSIFS (FR) | 1978-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227947-A1 | Phosphonate analogs for treating metabolic diseases | PHOSPHO1, G6PC1, PC | TSHR 2537/4885PPARD 334/4885TP53 2042/4885 |
| US-20090131372-A1 | PHOSPHONATE ANALOGS FOR TREATING METABOLIC DISEASES | PHOSPHO1, G6PC1, PC | TSHR 2537/4885PPARD 334/4885TP53 2042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.