Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | SUMO3 | P55854 | 1/20 | 0.35 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.35 |
| ▸ | SUMO1 | P63165 | 1/20 | 0.35 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2906805 | 0.85 | NPC1 (0.46) | RAB9ANPC1TSHRHTTSMN1; SMN2 | |
| SCHEMBL2251643 | 0.83 | NPC1 (0.44) | RAB9ANPC1TSHRHTTSMN1; SMN2 | |
| SCHEMBL2904364 | 0.82 | NPC1 (0.42) | RAB9ANPC1TSHRHTTSMN1; SMN2 | |
| SCHEMBL2908410 | 0.82 | NPC1 (0.46) | RAB9ANPC1TSHRHTTSMN1; SMN2 | |
| SCHEMBL13685704 | 0.81 | NCF1 (0.48) | RAB9ANPC1TSHRHTTSMN1; SMN2 | |
| SCHEMBL2906853 | 0.81 | KDM4E (0.54) | RAB9ANPC1TSHRHTTSMN1; SMN2 | |
| SCHEMBL2902503 | 0.81 | NPC1 (0.41) | RAB9ANPC1TSHRHTTSMN1; SMN2 | |
| SCHEMBL2908205 | 0.81 | NPC1 (0.41) | RAB9ANPC1TSHRHTTSMN1; SMN2 | |
| SCHEMBL2901754 | 0.81 | MEN1 (0.43) | RAB9ANPC1TSHRSMN1; SMN2LMNA | |
| SCHEMBL2907784 | 0.80 | NTRK1 (0.41) | RAB9ANPC1TSHRHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227628-A1 | 2-AMINOQUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-10 | — | — | US | claimed |
| EP-2262774-B1 | 2-aminoquinolines as 5-HT5A receptor antagonists, their manufacture and pharmaceutical compositions thereof | HOFFMANN LA ROCHE (CH) | 2012-11-14 | — | — | EP | disclosed |
| US-20090227628-A1 | 2-AMINOQUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227628-A1 | 2-AMINOQUINOLINES | HTR5A, HTR1A, HTR1E | RAB9A 152/4885NPC1 1213/4885TSHR 799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.