SCHEMBL410624

SCHEMBL410624

Brc1c[nH]c2ncccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AXL P30530 1/20 1.00
GPR84 Q9NQS5 1/20 0.58
LRRK2 Q5S007 1/20 0.55
KMT2A Q03164 1/20 0.55
PRKCI P41743 1/20 0.52
MET P08581 2/20 0.50
MAPK1 P28482 1/20 0.50
TGFBR1 P36897 3/20 0.49
PDPK1 O15530 2/20 0.49
IKBKE Q14164 2/20 0.49
MAP2K1 Q02750 1/20 0.49
CCNB2 O95067 1/20 0.47
CDK1 P06493 1/20 0.47
CCNB1 P14635 1/20 0.47
CCNB3 Q8WWL7 1/20 0.47
CDC7 O00311 3/20 0.46
CDK2 P24941 2/20 0.46
MAP4K4 O95819 2/20 0.46
PIM1 P11309 2/20 0.46
PRKACA P17612 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29655460 1.00 AXL (1.00) AXLGPR84LRRK2KMT2APRKCI
SCHEMBL5618155 0.78 TGFBR1 (0.71) AXLGPR84LRRK2KMT2ATGFBR1
SCHEMBL20846162 0.78 AXL (0.64) AXLGPR84TGFBR1PDPK1IKBKE
SCHEMBL2111969 0.75 AXL (0.60) AXLGPR84LRRK2KMT2AMET
SCHEMBL12605500 0.75 AXL (0.60) AXLGPR84LRRK2KMT2AMET
SCHEMBL5802606 0.75 AXL (0.60) AXLGPR84LRRK2KMT2AMET
SCHEMBL412615 0.75 AXL (0.60) AXLGPR84LRRK2KMT2AMET
SCHEMBL31097189 0.75 AXL (0.60) AXLGPR84LRRK2KMT2APRKCI
SCHEMBL368676 0.75 AXL (0.60) AXLGPR84LRRK2KMT2AMET
SCHEMBL12188 0.75 AXL (0.60) AXLGPR84LRRK2KMT2AMET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 388 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150284388-A1 PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES VERTEX PHARMACEUTICALS INCORPORATED 2015-10-08 US claimed
US-20150099884-A1 PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES VERTEX PHARMACEUTICALS INCORPORATED 2015-04-09 US claimed
US-20140309421-A1 PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES VERTEX PHARMACEUTICALS INCORPORATED 2014-10-16 US claimed
EP-2729465-A2 PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES Vertex Pharmaceuticals Incorporated (US) 2014-05-14 EP claimed
US-8513414-B2 Processes and intermediates for producing azaindoles VERTEX PHARMACEUTICALS INCORPORATED (US) 2013-08-20 US claimed
US-20130102782-A1 PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES VERTEX PHARMACEUTICALS INCORPORATED (US) 2013-04-25 US claimed
WO-2013006634-A9 PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES VERTEX PHARMACEUTICALS INCORPORATED (US) 2013-03-21 WO claimed
WO-2013006634-A2 PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES VERTEX PHARMACEUTICALS INCORPORATED (US) 2013-01-10 WO claimed
US-20260116903-A1 AROMATIC HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF RECURSION PHARMACEUTICALS INC (US) 2026-04-30 US disclosed
EP-4720058-A2 BIFUNCTIONAL DEGRADERS AND USES THEREOF Casma Therapeutics, Inc. (US) 2026-04-08 EP disclosed
US-12540149-B2 Aromatic heterocyclic compound, pharmaceutical composition, and use thereof RECURSION PHARMACEUTICALS, INC. (US) 2026-02-03 US disclosed
US-20250326772-A1 MRGPRX2 ANTAGONISTS, PHARMACEUTICAL COMPOSITION INCLUDING MRGPRX2 ANTAGONIST, AND METHOD OF TREATING MRGPRX2-MEDIATED DISEASE OR DISORDER KYORIN SEIYAKU KK (JP) 2025-10-23 US disclosed
US-20250326773-A1 MRGPRX2 ANTAGONISTS, PHARMACEUTICAL COMPOSITION INCLUDING MRGPRX2 ANTAGONIST, AND METHOD OF TREATING MRGPRX2-MEDIATED DISEASE OR DISORDER KYORIN SEIYAKU KK (JP) 2025-10-23 US disclosed
US-12448368-B2 Indole compounds as androgen receptor modulators NIDO BIOSCIENCES, INC. (US) 2025-10-21 US disclosed
US-20060100218-A1 Phosphodiesterase 4; asthma, chronic obstructive pulmonary disease, Alzheimer's disease, diffuse large-cell B cell lymphoma, and chronic lymphocytic leukemia; 8-[3-(3,4-dimethoxy-phenyl)-pyrrolo[2,3-b]pyridine-1-sulfonyl]-quinoline PLEXXIKON, INC. 2006-05-11 US disclosed
US-20060084674-A1 Azaindole thiazolinones CHEN SHAOQING 2006-04-20 US disclosed
WO-2006040049-A1 NOVEL AZAINDOLE THIAZOLINONES AS ANTI-CANCER AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2006-04-20 WO disclosed
WO-2006026754-A9 BICYCLIC HETEROARYL PDE4B INHIBITORS PLEXXIKON INC (US) 2006-04-20 WO disclosed
WO-2006026754-A2 BICYCLIC HETEROARYL PDE4B INHIBITORS PLEXXIKON, INC. (US) 2006-03-09 WO disclosed
WO-2005095400-A1 AZAINDOLES USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES VERTEX PHARMACEUTICALS INCORPORATED (US) 2005-10-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060100218-A1 Phosphodiesterase 4; asthma, chronic obstructive pulmonary disease, Alzheimer's disease, diffuse large-cell B cell lymphoma, and chronic lymphocytic leukemia; 8-[3-(3,4-dimethoxy-phenyl)-pyrrolo[2,3-b]pyridine-1-sulfonyl]-quinoline PDE4B, PDE4A, PDE4C AXL 4409/4885GPR84 2695/4885LRRK2 1803/4885
US-20150099884-A1 PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES JAK2, JAK3, JAK1 AXL 1344/4885GPR84 3870/4885LRRK2 1706/4885
US-20140309421-A1 PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES JAK2, JAK3, JAK1 AXL 1344/4885GPR84 3870/4885LRRK2 1706/4885
US-20250326772-A1 MRGPRX2 ANTAGONISTS, PHARMACEUTICAL COMPOSITION INCLUDING MRGPRX2 ANTAGONIST, AND METHOD OF TREATING MRGPRX2-MEDIATED DISEASE OR DISORDER MRGPRX2, MRGPRX1, MRGPRX4 AXL 4764/4885GPR84 545/4885LRRK2 1065/4885
US-12540149-B2 Aromatic heterocyclic compound, pharmaceutical composition, and use thereof CDK7, CDK17, CDK1 AXL 1612/4885GPR84 4000/4885LRRK2 1133/4885
US-20250326773-A1 MRGPRX2 ANTAGONISTS, PHARMACEUTICAL COMPOSITION INCLUDING MRGPRX2 ANTAGONIST, AND METHOD OF TREATING MRGPRX2-MEDIATED DISEASE OR DISORDER MRGPRX2, MRGPRX1, MRGPRX4 AXL 4764/4885GPR84 545/4885LRRK2 1065/4885
US-20260116903-A1 AROMATIC HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF CDK7, CDK8, CDK6 AXL 1089/4885GPR84 4087/4885LRRK2 1328/4885
US-20130102782-A1 PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES JAK2, JAK3, JAK1 AXL 1344/4885GPR84 3870/4885LRRK2 1706/4885
US-12448368-B2 Indole compounds as androgen receptor modulators AR, FSHR, ADRB3 AXL 3932/4885GPR84 181/4885LRRK2 199/4885
US-20060084674-A1 Azaindole thiazolinones CDK1, CDK2, CDK12 AXL 1304/4885GPR84 2985/4885LRRK2 1803/4885
US-20150284388-A1 PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES JAK2, JAK3, JAK1 AXL 1344/4885GPR84 3870/4885LRRK2 1706/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.