Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 4/20 | 0.55 |
| ▸ | CFTR | P13569 | 4/20 | 0.54 |
| ▸ | ACE | P12821 | 3/20 | 0.51 |
| ▸ | MMP3 | P08254 | 3/20 | 0.49 |
| ▸ | MMP8 | P22894 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8495772 | 0.90 | LMNA (0.61) | TDP1L3MBTL1LMNAPKMPOLB | |
| SCHEMBL29715382 | 0.86 | LMNA (0.55) | TDP1L3MBTL1LMNAPKMPOLB | |
| SCHEMBL23093165 | 0.86 | LMNA (0.55) | TDP1L3MBTL1LMNAPKMPOLB | |
| SCHEMBL29409296 | 0.85 | CFTR (0.57) | TDP1L3MBTL1LMNAPKMPOLB | |
| SCHEMBL28560316 | 0.85 | CFTR (0.57) | TDP1L3MBTL1LMNAPKMPOLB | |
| SCHEMBL4108015 | 0.84 | LMNA (0.50) | TDP1L3MBTL1LMNAPKMPOLB | |
| SCHEMBL4118662 | 0.83 | MEN1 (0.66) | TDP1L3MBTL1LMNAPKMPOLB | |
| SCHEMBL8383957 | 0.83 | MEN1 (0.66) | TDP1L3MBTL1LMNAPKMPOLB | |
| SCHEMBL11350319 | 0.81 | ACE (0.59) | TDP1L3MBTL1LMNAPOLBACE | |
| SCHEMBL4558064 | 0.80 | TAS1R3 (0.60) | TDP1L3MBTL1LMNAPKMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410130-B2 | Synthesis of 8H-3A-aza-cyclopenta [A ]indenes and 5,10-dihydropyrrolo[1,2-B]isoquinolines derivatives and their use as antitumor therapeutic agents | ACADEMIA SINICA (TW) | 2013-04-02 | — | — | US | disclosed |
| US-20090117125-A1 | SYNTHESIS OF 8H-3A-AZA-CYCLOPENTA[A]INDENES AND 5,10-DIHYDROPYRROLO[1,2-B]ISOQUINOLINES DERIVATIVES AND THEIR USE AS ANTITUMOR THERAPEUTIC AGENTS | MEMORIAL SLOAN KETTERING CANCER CENTER | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090117125-A1 | SYNTHESIS OF 8H-3A-AZA-CYCLOPENTA[A]INDENES AND 5,10-DIHYDROPYRROLO[1,2-B]ISOQUINOLINES DERIVATIVES AND THEIR USE AS ANTITUMOR THERAPEUTIC AGENTS | TOP2B, TOP2A, TOP1 | TDP1 264/4885L3MBTL1 2412/4885LMNA 2701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.